独活寄生汤加减结合透明质酸钠针关节腔注射治疗膝骨性关节炎

Clinical Efficacy Observation of Duhuo Jisheng Decoction Combined Sodium Hyaluronate Injection in Intra-articular Cavity Injection in Treatment of Knee Osteoarthritis

目的:探讨独活寄生汤加减结合透明质酸钠针关节腔注射膝骨性关节炎的疗效。方法对本院收治的150例膝骨性关节炎患者根据随机原则分为3组,每组50例。独活寄生汤组单独给予独活寄生汤加减进行治疗,透明质酸钠组单独给予透明质酸钠注射治疗,联合组注射透明质酸钠的同时服用独活寄生汤。对3组患者的疗效、VAS疼痛评分、血清C-反应蛋白水平以及不良反应进行比较。结果联合组的总有效率为94%,显著高于独活寄生汤组(80%)和透明质酸钠组(78%),差异具有统计学意义(P<0.05);治疗后联合组的VAS评分显著低于独活寄生汤组和透明质酸钠组,差异具有统计学意义(P<0.05);治疗后联合组的CRP水平相比较独活寄生汤组和透明质酸钠组均显著下降,差异具有统计学意义(P<0.05)。结论独活寄生汤加减结合透明质酸钠针关节腔注射治疗膝骨性关节炎疗效确切,能迅速缓解疼痛,改善功能,值得临床推广使用。

Objective： To explore the curative effect of Duhuo Jisheng decoction combined with sodium hyaluronate injection in articular cavity injection in the treatment of knee osteoarthritis.Method： One hundred and fifty cases of patients with knee osteoarthritis received in our hospital were randomly divided into three groups according with 50 cases in each group.Duhuo Jisheng decoction group was given alone Duhuo Jisheng decoction for the treatment,sodium hyaluronate group was given sodium hyaluronate injections alone,combined group was given injection of sodium hyaluronate and taken Duhuo Jisheng decoction.The efficacy,VAS pain scores,serum Creactive protein levels and adverse reactions in the three groups of patients were compared.Result： The total effective rate in combination group was 94%,significantly higher than Duhuo Jisheng decoction group（80%） and sodium hyaluronate group（78%）,the differences were statistically significant（P 0.05）;VAS scores in combination group after treatment was significantly lower than Duhuo Jisheng decoction group and sodium hyaluronate group,the differences were statistically significant（P 0.05）;CRP levels in combination group after treatment were significantly decreased compared with Duhuo Jisheng decoction group and sodium hyaluronate group,the differences were statistically significant（P 0.05）.Conclusion Duhuo Jisheng decoction combined intra-articular injection sodium hyaluronate for the treatment of knee osteoarthritis had good efficacy,could quickly relieve pain and improve function,worthy of clinical promotion.