鸟氨酸脱羧酶抗酶作为肿瘤治疗靶点的潜在价值

Ornithine decarboxylase antizyme as the potential target for cancer therapy

鸟氨酸脱羧酶抗酶(OAZ),在细胞生长分化中起重要调控功能的蛋白,因其具有独特的翻译框移机制、在多胺代谢中的重要调控地位以及诱导部分细胞内重要大分子的非泛素依赖降解作用而备受研究者关注。本文概述了目前对OAZ作用机制的认识,并从细胞周期、分化、凋亡及遗传稳定性的调节上探讨其在细胞活动中的作用。近年来,OAZ已成为肿瘤治疗的潜在靶点,在实体瘤如肝癌细胞、肺癌细胞中,OAZ的高表达与细胞生长抑制明显相关,体现其抗肿瘤特性.对其作用机制的深入了解,将有助于充分挖掘抗酶在肿瘤治疗中的应用价值。

Ornithine decarboxylase antizyme （OAZ）, a protein playing important role in regulating cell growth and differentiation, has been the concern of the researchers in that it has unique translational frame-shift mechanism, regulates the cellular polyamine metabolism and could induce the ubiquitin-independent degradation of some impor- tant cellular macromolecules. In this paper, we summarize the current understanding of OAZ^s mechanisms and dis- cuss its regulatory function in cell cycle, cell differentiation, cell apoptosis and genomic stability. At present, OAZ has become the potential target for tumor therapy. In some solid tumors such as liver cancer, lung cancer, the high expression of OAZ protein was obviously relevant with cell growth inhibition, and this demonstrates its anti-cancer properties. Therefore, the further understanding of its functional mechanism will help to fully exploit the application in cancer treatment.