摘要
药用植物中萜类次生代谢产物种类丰富,数量巨大,其现代药理活性相当突出。3-羟基-3-甲基戊二酰辅酶A还原酶(3-hydroxy-3-metllylglutaryl coenzyme A reductase,HMGR)作为萜类成分甲羟戊酸(MVA)合成途径上第一个重要限速酶,对药用植物萜类活性成分生物合成过程起着至关重要的作用。文章系统综述了HMGR的生物学意义、催化机制,HMGR克隆情况、基因结构、以及在重要药用植物丹参、甘草、红豆杉等中的研究进展。
There exists many kinds and a huge number of terpenoid in medicinal plants, which show a wide range of pharma- cological activities. 3-Hydroxy-3-metllylglutaryl coenzyme A reductase(HMGR) is a key rate-limiting enzyme in terpenoid biosynthetic pathway. HMGR plays an important role in the regulation of secondary metabolism of the terpenoid. The paper summarized the biologi- cal function and the catalytic mechanism of HMGR, the cloning and the structure of the gene as well as its research progress in some medicinal plants.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2013年第19期3226-3233,共8页
China Journal of Chinese Materia Medica
基金
全国优秀博士学位论文作者专项资金项目(201188)
北京市属高等学校高层次人才引进与培养计划项目(CIT&TCD201304174)
北京市优秀人才培养资助个人项目(2011D005018000002)
关键词
HMGR
萜类化合物
药用植物
3-hydroxy-3-metllylglutaryl coenzyme A reductase
terpenoid
medicinal plants