双花千里光中一个新的艾里莫芬烷型倍半萜

A new eremophilane derivative from Senecio dianthus

利用多种色谱技术对藏药双花千里光Senecio dianthus地上部分95%乙醇浸提物进行分离纯化,共得到5个化合物,根据理化数据和波谱数据鉴定化合物的结构分别为:艾里莫芬-9(10),7(11)-二烯-8-酮-12-羧酸-β-D-吡喃葡萄糖苷,命名为双花千里光苷A(1),5,7,4'-三羟基-黄酮-3-O-β-D-葡萄糖苷(2),槲皮素-3-O-β-D-葡萄糖苷(3),金丝桃苷(4),芦丁(5)。其中,化合物1为新化合物,化合物2,4,5均为首次从双花千里光中分离得到。

A new eremophilane derivative, 4,5,11 -trimethyl-9 （ 10）, 7 （ 11 ） -eremophiladien-8-keto-12-carboxylic acid-β-D- glucopyranoside（which named dianthuside A） 1 and four known compounds, 5,7,4＇-trihydroxy-flavonone-3-O-β-D-glucoside （2）, quercetin-3-O-β-D-glucoside （3）, hyperin（4） and rutin （5） have been isolated from the aerial part of Senecio dianthus. Their structures were elucidated by physicochemical properties and spectroscopic data analysis. Compounds 2, 4 and 5 were isolated from this plant for the first time.