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DLC-1和FAI-1蛋白在卵巢癌组织中的表达及其临床意义 被引量：2

Expression and clinical significance of DLC1 and PAI-1 protein in ovarian carcinoma
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摘要 目的研究肝癌缺失基因-1（DLC1）和I型纤溶酶原激活剂抑制剂（PAI-1）在卵巢上皮性癌组织中的表达情况，探讨DLC1和PAI-1在卵巢癌组织发生发展中的作用。方法采用免疫组织化学染色法分别检测正常卵巢和卵巢上皮性癌组织中DLC1和PAI-1的蛋白的表达。结果①卵巢上皮性癌组织中DLC-1蛋白表达低于正常卵巢组织（P〈0．05）；DLC1蛋白的低表达与卵巢癌的临床分期、腹水形成和淋巴结转移相关（P〈0．05）。②卵巢上皮性癌组织中PAI—1蛋白表达高于正常卵巢组织（P〈0．05）；PAI-1蛋白的高表达与卵巢癌的临床分期、分化程度和淋巴结转移相关（P〈0．05）。③卵巢癌组织中DLC1与PAI-1的蛋白表达之间呈负相关（rp=-0．256，P=0．027）。结论DLC1低表达或表达缺失和PAI-1的高表达可能与卵巢上皮性癌的发生、发展有关。DLC1和PAI-1的联合检测有助于判断卵巢癌的恶性程度。 Objective To investigate the expression levels of deleted in liver cancer （DLC-1） gene and plasminogen activator inhibitor （ PAI-1 ） gene in epithelial ovarian cancer and the effect of DLC-1 on the occurrence and development of epithelial ovarian cancer. Methods Immunohistochemical stai-ning was used to examine the expression of DLC1 and PAI-1 protein in 25 cases of normal ovarian tis-sues, 52 cases of serous cystadenocarcinoma tissues and 23 cases of mucinous cystadenocarcinoma tis-sues. Results DLC1 and PAI-1 protein were detected mainly located in the cytoplasm, which was found in ovarian carcinoma and normal ovarian tissues. The expression of DLC1 protein in ovarian carcinoma tissues was significantly lower than that in normal ovarian tissues, whereas it was converse for the expres-sion of PAI-1 protein. The expression of DLC1 and PAI-1 protein were significantly correlated with clini-cal stage and lymphnode metastasis. The expression of DLC1 was negatively correlated with the expression of PAI-1 protein. Conclusions The expression of DLC1 and PAI-1 protein may play an important role in the progression and metastasis of ovarian carcinoma. The combined detection of DLC1 and PAI-1 can help determine the degree of malignancy of ovarian cancer.
作者 任芳 史惠蓉 张瑞涛 贾艳艳 冯巍
机构地区 郑州大学第一附属医院妇产科
出处 《中国实用医刊》 2013年第20期9-11,共3页 Chinese Journal of Practical Medicine
基金 河南省医学科技攻关计划重大项目（20090113）
关键词 肝癌缺失基因-1 I型纤溶酶原激活剂抑制剂 免疫组织化学 卵巢上皮性癌 Deleted in liver cancer-1 Plasminogen activator inhibitor-l Immunohistochemis-try Epithelial ovarian cancer
分类号 R737.31 [医药卫生—肿瘤]
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参考文献11

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共引文献8

同被引文献40

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中国实用医刊
2013年 第20期

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