瑞舒伐他汀钙对不稳定型心绞痛患者血脂及C-反应蛋白的影响

Effect of rosuvastatin calcium on lipids and inflammatory factors C-reactive protein in patients with unstable angina

目的探讨瑞舒伐他汀钙对不稳定型心绞痛患者血脂及炎症因子C-反应蛋白的影响。方法将70例患者随机分为治疗组和对照组，每组35例，对照组以硝酸酯类、B-受体阻滞剂、血管紧张素转换酶抑制剂、抗血小板作为常规治疗，治疗组在常规治疗基础上给予瑞舒伐他汀钙治疗，比较两组用药前后C-反应蛋白水平及血脂变化。结果两组治疗后C-反应蛋白及血脂水平均较前降低，治疗组下降明显优于对照组，两组比较差异有统计学意义（P〈0．05）。结论瑞舒伐他汀钙治疗不稳定型心绞痛不但能降低血脂，还可减轻其炎性反应，稳定动脉粥样斑块。

Objective To investigate the effect of rosuvastatin calcium on lipids and inflammato-ry factors C-reactive protein in patients with unstable angina. Methods Totally seventy patients with un-stable angina were chosen in the study. The patients were randomly divided into two groups： the control group （ n = 35 ） and the therapeutic group （ n = 35 ）. The patients in control group were treated by routine therapy with nitrates, B-blockers, ACEI and antibloodplatelet therapy. The patients in therapeutic group were treated with rosuvastatin calcium on the basis of routine therapy. The levels of C-reactive protein and lipids were measured before and after treatment in both groups. Results After treatment, the level of C-reactive protein and lipids decreased. And the therapeutic group decreased more than the control group, the difference was statistically significant （ P 〈 0.05 ）. Conclusions Rosuvastatin calcium in treatment of unstable angina can not only reduce cholesterol, but also reduce the inflammatory response, so it is conducive to atherosclerosis plaque stability.