摘要
目的探讨分化相关基因NDRG1和趋化因子受体CXCR7在胰腺癌组织中的表达及其临床意义。方法利用免疫组化sP法检测52例胰腺癌和17例正常胰腺组织NDRG1和CXCR7的表达，分析其与胰腺癌临床病理特征的关系。结果胰腺癌、正常胰腺组织中NDRG1蛋白表达率分别为73．1％（38／52）、23．5％（4／17）。NDRG1蛋白在胰腺癌组织中高表达，显著高于正常胰腺组织（P〈0．05），NDRG1蛋白的表达与胰腺癌是否淋巴结转移、组织病理分级及临床分期相关（P〈0．05）；胰腺癌、正常胰腺组织中CXCR7蛋白表达率分别为67．3％（35／52）、17．6％（3／17）。CXCR7蛋白在胰腺癌组织高表达，显著高于正常胰腺组织（P〈0．05），CXCR7蛋白的表达与胰腺癌是否淋巴结转移、组织病理分级及临床分期相关（P〈0．05）。NDRG1与CXCR7在胰腺组织中的表达呈正相关关系（P〈0．05，r=0．378）。结论NDRG1、CXCR7在胰腺癌发生发展的不同阶段可能起着重要的作用，两者在促进肿瘤转移方面具有一定的正相关性。
Objective To investigate the expression and clinical significance of CXCR7 and NDRG1 in pancreatic carcinoma. Methods The expressions of NDRG1 and CXCR7 protein in 52 cases of pancreatic carcinoma tissues and 17 cases of normol pancreatic tissues were examined by immunohisto-chemical SP staining, and its relationship with clinicopathological parameters was analyzed. Results The positive expression rates of NDRG1 protein was 73.1% （ 38/52 ） and 23.5% （4/17） in pancreatic carcino- ma and normol pancreatic tissues. NDRG1 was highly expressed in pancreatic carcinoma. The rate was significantly higher than that in normol pancreatic tissues group （ P 〈 0. 05 ）. The expression of NDRG1 was significantly correlated with lymph node metastasis, histopathological grade and clinical stage （P 〈 0. 05 ）. The positive expression rates of CXCR7 protein were 67.3% （35/52）and 17.6% （3/17）in pan-creatic carcinoma and normal pancreatic tissues. CXCR7 was highly expressed in pancreatic carcinoma. The rate was significantly higher than that in normal pancreatic tissues group （ P 〈 0. 05 ）. The expression of CXCR7 was significantly correlated with lymph node metastasis, histopathological grade and clinical stage （P 〈 0. 05 ）. There was positive correlation between the expression of NDRG1 and CXCR7 （P = 0. 003 ,r = 0. 378 ）. Conclusions NDRGland CXCR7 may play an important role in the different stage of pancreatic carcinoma, especially with a positive correlation in promoting tumor metastasis.
出处
《中国实用医刊》
2013年第20期55-57,共3页
Chinese Journal of Practical Medicine
