风寒表证模型小鼠体重及脾脏和胸腺脏器系数变化的实验研究

The experimental study on the changes of the organic coefficient of spleen and thymus in the wind cold superficies syndrome model mice

目的探讨风寒表证模型小鼠体重及脾脏和胸腺脏器系数的变化。方法200只小鼠（雌雄各半）随机分为对照组和实验组，对照组动物在18～21℃室温环境中饲养。实验组动物放置温度2—5℃，湿度60％，风速4—5级，自然光线环境中饲养。于实验开始第7天（造模成功）、第10天和第14天分三批次，分别先称体重然后处死，采集脏器称重并计算脾脏和胸腺脏器系数。结果对照组体重、脾和胸腺重量均随饲养天数增加而增加，脾脏系数上升，胸腺系数较恒定；实验组普遍出现风寒表证状况，小鼠体重先减后增，脾脏重量增加，而系数变化不明显，且系数均高于对照组，胸腺质量变化不大，但系数下降明显。结论风寒表证模型小鼠造模期及恢复期体重变化较大，脾脏和胸腺系数受体重影响较大，也与脏器代偿性增大有一定关系。

Objective To study the changes of the organic coefficient of the spleen and thymus in the wind cold superficies syn- drome model mice. Methods 200 rats in each group and half male and half female were randomly divided into control group and experimental group. The control animals were fed at room temperature 18 -21℃. The experimental animals were fed under natural light with temperature 2 -5℃, humidity 60% and wind 4 -5 grades. The control group and experimental group were weighed and then killed on the day7 ,daylO and day14 ,their spleen and thymus were taken and weighed to calculate organic coefficient. Results The weights of body, spleen and thymus of control group had a gradual increase with days accumulated. The organic coefficients of spleen rose and of thymus were relatively constant. The wind cold superficies syndromes have been widespread in the experimental group. The body weights of mice were decreased when the wind cold superficies syndrome model was success and then increased. The weights of spleen were decreased, but organic coefficients of spleen hadn＇t a significant change, and their coefficients were higher than that of the control group. The weights of thymus were relatively constant, but organic coefficients of thymus had a significant decline. Conclusion The body weights of the wind cold superficies syndrome model mice had a significant change. The organic coefficients of spleen and thymus were affected by the weight of body and by compensatory increase of spleen and thymus.