犬与兔两种顶端动脉瘤模型的建立与比较

Establishment and comparision of terminal aneurysm models in canines and rabbits

目的 建立犬与兔两种顶端动脉瘤模型并比较.方法 分别选用10条犬和25只兔,采用血管移植法结合酶诱导法分别制成犬与兔的顶端动脉瘤模型.结果 建立犬顶端动脉瘤模型10个,1例术后1d破裂,犬动脉瘤模型建立术后的直径为（5.20±0.37） mm（n=10）,术后3周动脉瘤直径为（5.42±0.42） mm（n =9）,两者差异无统计学意义（P＞0.05）.建立兔顶端动脉瘤模型25个,3例分别于术后1、14、16d破裂,兔动脉瘤模型建立术后的直径为（2.10 ±0.22） mm（n=25）,术后3周动脉瘤直径为（3.02±0.36） mm（n =22）,两者差异有统计学意义（P＜0.05）.结论 血管移植法结合酶诱导法制作动脉瘤模型成功率高、成本低,在形态、病理方面与临床动脉瘤更加相似.犬动脉瘤模型手术耐受力强、存活率高,适合行造影及介入栓塞实验.兔动脉瘤模型具有自发生长、自发破裂的生物学特点,适合进行组织学和病理学研究.

Objective To establish and compare terminal aneurysm models in canines and rabbits.Methods Terminal aneurysm models in 10 canines and 25 rabbits were established by using an arterial pouch pre-digested in vitro with combined elastase and collagenase.Results Ten terminal aneurysm models in canines were established,and one model ruptured at the first day after the construction.The aneurysmal models enlarged from the initial diameters of （5.20 ±0.37） mm （n =10） to （5.42 ±0.42） mm （n =9） at 3rd week after establishment （P ＞ 0.05）.Twenty-five terminal aneurysm models in rabbits were established,and three models ruptured at the first day,14th day and 16th day respectively after the construction.The aneurysmal models enlarged from the initial diameters of （2.10 ± 0.22） mm （n =25） to （3.02 ±0.36） mm （n=22） at 3rd week after establishment （P＜0.05）.Conclusion The successful rate of terminal aneurysm models in our group is high and the cost is low.The models are quite similar to the human intracranial aneurysm morphologically and pathologically.The models in canines endure more,have a high survival rate and are very useful for the study of angiography and embolization.The models in rabbits could spontaneously grow and rupture and are very useful for the study of histology and pathology.