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抑郁症患者改良性电抽搐治疗的疗效与色氨酸羟化酶2基因多态性的关系 被引量：2

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摘要 目的:探讨汉族人群抑郁症患者色氨酸羟化酶2(TPH2)基因rs1386494多态性与改良性电抽搐治疗(MECT)效果的关系。方法:研究对象为100例抑郁症患者,应用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)技术检测TPH2基因rs1386494多态性,接受MECT治疗,使用汉密顿抑郁量表(HAMD)评定疗效。结果:患者经MECT治疗后HAMD评分较治疗前有显著性降低;THP2基因rs1386494基因型及等位基因频率在不同疗效组间的分布,差异无统计学意义;HAMD总减分及各因子分减分在不同基因型频率间的分布,差异均无统计学意义。结论:MECT是治疗抑郁症的有效方法,但其治疗效果可能与TPH2基因rs1386494多态性无关。
作者 张春平 黄雄 何红波 余晓仪 王志杰 江妙玲 古智文 张敏玲
机构地区 广州市精神病医院
出处 《实用医学杂志》 CAS 北大核心 2013年第19期3183-3185,共3页 The Journal of Practical Medicine
基金 国家临床重点专科(精神科)建设项目
关键词 抑郁症 色氨酸羟化酶2 改良性电抽搐治疗 基因多态性
分类号 R749.4 [医药卫生—神经病学与精神病学]
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参考文献7

  • 1Lopez de Lara C, Brezo J, Rouleau G, et al. Effect of tryptophan hydroxylase-2 gene variants on suicide risk in major depression[J]. Biol Psychiatry, 2007 , 62 ( 1 ) : 72-80.
  • 2UK ECT Review Group. Efficacy and safety of electroeonvulsive therapy in depressive disorders: a systematic review and meta- analysis [J]. Lancet, 2003,361 (9360) : 799- 808.
  • 3Kellner C. Brain Stimulation in psychiatry: ECT, DBS, TMS, and other modalities [ M ]. Cambridge UK : CambridgeUniversity Press, 2012.
  • 4Swartz C M. Eleetroeonvulsive and neuromodulation Therapies [ M ]. New York : Cambridge University Press, 2009.
  • 5Anttila S, Huuhka K, Huuhka M, et al. Interaction between TPH1 and GNB3 genotypes and electroconvulsive therapy in major depression [J]. J Neural Transm,2007,114 (4):461 - 468.
  • 6Anttila S, Huuhka K, Huuhka M, et al. Catechol-O- methyltransferase (COMT) polymorphisms predict treatment response in electroconvulsive therapy [J ]. Pharmacogenomics J, 2008,8 (2):113-116.
  • 7Anttila S, Viikki M, Huuhka K, et al. TPH2 polymorphisms may modify clinical picture in treatment-resistant depression [ J ]. Neurosci Lett. 2009.464 ( 1 ) : 43-46.

同被引文献20

  • 1GuptaM, Bhatnagar P, Grover S, et ol. Association studies of catechol-O- methyltransferase (COMT) gene with schizophrenia and response to an- tipsychotic treatment [J] . Pharmacogenomics, 2009, 10 (3) : 385-397.
  • 2Kneavel M, Gogos J, Karayiorgou K, et al. Interaction of COMT gene deletion and enviromnent on cognition [J] . Soc Neurosci A bstr, 2000, 26 (1-2) :571-580.
  • 3Woodward ND, Jayathilake K, Meltzer HY, et aL COMT val 158 met genotype, cognitive function, and cognitive improvement with clozapine in schizophrenia [J] . Schizophr Res, 2007, 90 (1-3) : 86-96.
  • 4Massat I, Souery D, Del-Favero J, et al. Association between COMT (Va115s Met) functional polymorphism and early onset in patients with major depressive disorder in a European muhicenter genetic associa- tion study[J] . Mol Psychiatry, 2005, 10 (6) : 598-605.
  • 5Heyer NJ, Echeverria D, Martin MD, et ol. Catechol-O-methyhrans ferase(COMT) VAL^158 MET functional polymorphism, dental mercury exposm'e, and elfreported symptoms and mood [J] . J Toxicol EnvirorL Health A, 2009, 72 (9) : 599-609.
  • 6Honea R, Verchinski BA, Pezawas L, et al. Impact of interacting func- tional variants in COMT on regional gray matter volume in human brain[J] . Neuroimage, 2009, 45 (1) : 44-51.
  • 7Congdon E, Constable RT, Lesch KP, et al. Influence of SLC 6A3 and COMT variation on neural activation during response inhibition [J] . Biol Psychol, 2009, 81 (3) : 144-152.
  • 8Mandelli L, Seetti A, Marino E, et al. Interaction between serotonin trans porter gene, catechol-O-methyltransferase gene and stressful life events in mood disorders [J] . lnt JNeuropsychopharmacol, 2006, 6(7) : 1-11.
  • 9Lee HY, Kim YK. Catechol-O-methyltransferase VaP58 Met polymor- phism affects therapeutic response to mood stabilizer in symptomatic manic patients [J] . Psychiatry Res, 2010, 175 (1-2) : 63-66.
  • 10Heyer NJ, Echeverria D, Martin MD, et al. Catechol-O-methyhrans- ferase(COMT) VAL^158 MET functional polymorphism, dental mercury exposure, and elfreported symptoms and mood [J] . J Toxicol Environ Health A, 2009, 72 (9) : 599-609.

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实用医学杂志
2013年 第19期

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