摘要
目的:采用Meta分析方法评价XPD Lys751G1n核苷酸多态性与皮肤黑色素瘤(cutaneous melanoma,CM)的相关性。方法:全面检索相关文献,采用Stata12.0软件进行统计分析。结果:共纳入9个病例一对照研究。在Lvs751GIn多态性位点等位基因模式中,与野生基因型A相比,C合并的OR值(95%CI)为1.05(1.01~1.09);显性模式中与AA相比,CC+CA合并的0R值(95%CI)为1.13(1.03~1.24);共显性模式中与AA相比,CC合并的OR值(95%CI)为1.04(1.00-1.08);其余为阴性结果。结论:C等位基因可能是CM的易感基因。
Objective To evaluate the correlation between Lys751 Gin nucleotide polymorphisms and cutaneous melanoma (CM) by meta analysis. Methods Relevant literatures were searched and then the meta-analysis was conducted by Stata 12.0 software. Results A total of 9 case-control studies were involved. In allele model of Lys751Gln polymorphism, the OR value of genotype C was 1.05 (95% CI was 1.01- 1.09) as compared to wild genotype A. In dominant model, the OR value of CC+CA was 1.13 (95% CI was 1.03 - 1.24) as compared to AA. In co-dominant model, the OR value of CC was 1.04 (95%CI was 1.00-1.08) as compared to AA. The emaining results were negative. Conclusion C allele may be the susceptibility marker gene of CM.
出处
《实用医学杂志》
CAS
北大核心
2013年第19期3237-3240,共4页
The Journal of Practical Medicine
基金
广西壮族自治区科学技术厅基金资助项目(编号:桂科攻1140003B-86)