XPD Lys751Gln核苷酸多态性与皮肤黑色素瘤易感性关系的Meta分析

Correlation between the XPD Lys751Gln nucleotide polymorphisms and cutaneous melanoma:a Meta-analysis

目的：采用Meta分析方法评价XPD Lys751G1n核苷酸多态性与皮肤黑色素瘤（cutaneous melanoma,CM）的相关性。方法：全面检索相关文献，采用Stata12．0软件进行统计分析。结果：共纳入9个病例一对照研究。在Lvs751GIn多态性位点等位基因模式中，与野生基因型A相比，C合并的OR值（95％CI）为1．05（1．01～1．09）;显性模式中与AA相比，CC＋CA合并的0R值（95％CI）为1．13（1．03～1．24）；共显性模式中与AA相比,CC合并的OR值（95％CI）为1．04（1．00-1．08）；其余为阴性结果。结论：C等位基因可能是CM的易感基因。

Objective To evaluate the correlation between Lys751 Gin nucleotide polymorphisms and cutaneous melanoma （CM） by meta analysis. Methods Relevant literatures were searched and then the meta-analysis was conducted by Stata 12.0 software. Results A total of 9 case-control studies were involved. In allele model of Lys751Gln polymorphism, the OR value of genotype C was 1.05 （95% CI was 1.01- 1.09） as compared to wild genotype A. In dominant model, the OR value of CC＋CA was 1.13 （95% CI was 1.03 - 1.24） as compared to AA. In co-dominant model, the OR value of CC was 1.04 （95%CI was 1.00-1.08） as compared to AA. The emaining results were negative. Conclusion C allele may be the susceptibility marker gene of CM.