基于磁性粒子成像技术的一维建模仿真研究

Simulation Research on One-Dimensional Magnetic Particle Imaging

磁性粒子成像(Magnetic Particle Imaging,MPI)是一种新兴的医疗成像方式,对于空间中的磁纳米粒子分布具有极高的灵敏度,同时也克服了电离辐射的影响。MPI能够获得关于磁性粒子的高质量的图像,具有高时空分辨率。为了研究MPI中图像准确重建的相关问题,首先简要介绍了MPI的成像原理,并根据基本原理建立了一维模型,同时在MATLAB中对模型进行仿真,分析了影响MPI浓度测量精度的三个重要因素及影响方式,仿真结果显示这三种因素对MPI浓度测量精度的影响呈现出一定的规律性,最后从信号处理的角度对上述规律给出合理的解释。仿真试验的分析将对MPI中图像的重建起到了指导作用。

Magnetic particle imaging （MPI） is a new tomographic imaging modality sensitive to the spatial distribution of magnetic nanoparticles（MNPs）.The purpose of this paper was to study the related problems of image reconstruction in MPI.Therefore,we firstly presented an introduction to the basic function principle of MPI and built a one -dimensional model of MPI through MATLAB based on this basic principle,together with an estimation of the impact of three important factors in MPI on the measurement accuracy of concentration of MNPs.The simulation results show that there may be a certain regularity for the three factors on the influence to the precision of MPI concentration measurement.Furthermore,through an analysis of the simulation results in terms of signal processing,this paper gave a reasonable explanation.The analysis of the simulation results will play an important guiding role in building MPI platform.