产后与非产后抑郁症患者听感觉门控的对比

Auditory Sensory Gating Potential between Postpartum and Non-postpartum Depressions

目的探讨产后与非产后抑郁症患者听感觉门控P50的变化差异特征,以便为产后抑郁症提供易感性指标。方法采用配对听觉条件(S1)、测试(S2)刺激范式,对30例产后抑郁症患者(产后组)、32例非产后抑郁症患者(非产后组)进行听觉诱发电位P50检测,测量P50的潜伏期、波幅,并与30例健康被试(对照组)进行比较。结果①与对照组相比,S1-P50,S2-P50潜伏期产后组差异不显著;非产后组潜伏期显著延迟(S1-P50,t=2.52,P<0.05;S2-P50,t=2.68,P<0.05);②与对照组相比,产后组S1-P50波幅显著降低(t=3.04,P<0.05),S2-P50波幅差异不显著,非产后组S1-P50,S2-P50波幅均显著降低(t=3.46,2.44;P<0.05);③对照组、产后组、非产后组S2/S1波幅比值依次显著升高(χ2=4.22,P<0.05)。结论产后与非产后抑郁症患者感觉门控抑制能力均有缺陷,产后抑郁患者的缺陷是间于健康与非产后抑郁症中的一种亚健康的状态性受损。

Objective To explore the change different characteristics on the P50 auditory sensory gating potential between post- partum and non-postpartum depressions,and provide a susceptibility index for the postpartum depression. Methods PS0 was mea- sured by using paired clicks auditory condition/testing stimulating paradigm when 30 cases postpartum depressions（postpartum de- pression group,PPDG）and 32 cases non postpartum depressions（non postpartum depression group,NPPDG）were tested by event- related potentials system,and measuring the incubation period and amplitude of PS0. Compared with the results of 30 cases healthy subjects （control group,CG）. Results ①Compared with CG,S1--P50 and S2--P50 latencies were no significant differences in PPDG （P〉0. 05） ,and S1--P50（t： 2.52 ,P〈0.05） ,S2--P50（t= 2.68 ,P〈0.05）latencies were significantly longer in NPPDG. ② Compared with CG,the amplitude of S1- P50 was significantly lower （t： 3.04 ,P〈0.05）,and the amplitude of S2--PS0 was no significant difference （P〈0. 05）in PPDG,and the amplitude of S1- P50 and S2--P50 were significantly lower in NPPDG （t = 3.46,2.44 ;P〈0.05）. ③ The amplitude ratio of S2/S1 was gradually significantly higher in CG ,PPDG ,and NPPDG（Z2= 4.22 ,P d0.05）. Conclusion Postpartum and non-postpartum depressions present defect on the inhibiting ability of auditory sensory gat- ing potential in a certain extent. The defect in postpartum＇depression is a sub-health state damage between health subjects and non postpartum depression.