CD4＋CD28-T细胞在急性冠脉综合征中的作用研究进展

Progress in the study on the role of CD4＋ CD28-T cells in acute coronary syndrome

近年来,在急性冠脉综合征（ACS）患者的粥样斑块中和外周血中发现一种不寻常的细胞,即CD4＋CD28T淋巴细胞.该细胞以分泌Thl型细胞因子为主,具有大量扩增和寿命长的特征,且具有细胞毒性T细胞（CTL）的功能.这种T细胞亚群在斑块中的堆积引起了斑块的不稳定,参与ACS的发生.因而对该细胞的研究将为ACS的预防和治疗提供新的途径.

In recent years,the unusual CD4＋CD28T cells were found in the atheromatous plaque and peripheral blood in patients with acute coronary syndrome.The cells that expand largely and survive for a long time mainly secrete Thl cytokines.In addition,the CD4＋CD28-T cells also have cytotoxicity.Accumulation of CD4＋CD28-T cells causes plaque instability and involve in the development of acute coronary syndrome.The study on CD4＋CD28-T cells could provide novel means to prevent and cure acute coronary syndrome.