2Ashworth TR.A case of cancer in which cells similar to those in the tumors were seen in the blood after death.Aust med J,1869,14,146.
3Molnar B,Sipos F,Galamb O,et al.Molecular detection of circulating cancer cells Role in diagnosis prognosis and follow-up of colon cancer patients.Dig Dis,2003,21(4):320-325.
4Leon SA,Shapiro B,Sklar off DM,et al.Free DNA in the serum of cancer patients and the effect of therapy.Cancer Res,1977,37:646-650.
5Chiu RW,Chan LY,Lam NY,et al.Quantitative analysis of circulating mitochondrial DNA in plasma.Clin Chem,2003,49:719-726.
6Combaret V,Audoynaud C,Iacono I,et al.Circulating MYCN DNA as a tumor-specific marker in neuroblastoma patients.Cancer Res,2002,62:3646-3648.
7Gotoh T,HosoiH,IeharaT,etal.PredictionofMYCN amplification in neuroblastoma using serum DNA and real-time quantitative polymerase chain reaction.Clin Oncol,2005,23:5205-5210.
8Ji XQ,Sato H,Tanaka H,et al.Real-time quantitative RTPCR detection of disseminated endometrial tumor cells in peripheral blood and lymph nodes using the LightCycler System.Gynecol Oncol,2006,100:355-360.
9Goodman OB Jr,Fink LM,Symanowski JT,et al.Circulating tumor cells in patients with castration-resistant prostate cancer baseline values and correlation with prognostic factors.Cancer Epidemiol Biomarkers Prev,2009,18(6):1904-1913.
4Pantel K, Brakenhoff R H, Brandt B. Detection, clinical relevance and specific biological properties of disseminating turnout cells[J]. Nat Rev Cancer, 2008,8(5) :329-340.
5Hayes D F, Smerage J. Is there a role for circulating tumor cells in the management of breast cancer? [J]. Clin Cancer Res, 2008, 14 (12):3646-3650.
6Riethdorf S, Pantel K. Disseminated tumor ceils in bone marrow and circulating tumor cells in blood of breast cancer patients: current state of detection and characterization[J]. Pathobiology, 2008,75 (2) : 140-148.
7Alix Panabieres C, Riethdorf S, Pantel K. Circulating tumor cells and bone marrow micrometastasis[J]. Clin Cancer Res, 2008, 14 (16): 5013-5021.
8Husemann Y, Geigl J B, Schubert F, et al. Systemic spread is an early step in breast cancer[J]. Cancer Cell, 2008,13(1):58- 68.
9Lang J E, Hall C S, Singh B. Significance of micrometastasis in bone marrow and blood of operable breast cancer patients: research tool or clinical application? [J]. Expert Rev Anticancer T her, 2007,7(10):1463-1472.
10Pantel K, Brakenhoff R H. Dissecting the metastatic cascade[J]. Nat Rev Cancer, 2004, 4(6) : 448-456.
