N-乙酰半胱氨酸治疗慢性阻塞性肺疾病的研究进展

Updates of N-acetylcysteine in the treatment of chronic obstructive pulmonary disease

慢性阻塞性肺疾病的发病与气道、肺实质和肺血管的慢性炎症、肺部的蛋白酶和抗蛋白酶失衡、氧化与抗氧化失衡等有关。其中氧化／抗氧化失衡是造成慢性阻塞性肺疾病慢性全身损伤的重要原因。N-乙酰半胱氨酸具有抗氧化及细胞保护作用，本文对近年来N-乙酰半胱氨酸治疗慢性阻塞性肺疾病的研究进展作一综述。

The pathogenesis of chronic obstructive pulmonary disease （COPD） is related to chronic inflammation of airway, lung parenchyma and lung vascular, imbalance of anti-protease and protease, as well as imbalance of oxidation and antioxidation in the lung. Oxidation and antioxidation imbalance is one of the most important reasons for systemic manifestations of COPD. N-acetylcysteine might provide antioxidation and cell protection. In this review article, we will summarize the research progress of N- acetylcysteine in the treatment of COPD.