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肺痿冲剂方配合大剂量N-乙酰半胱氨酸二联治疗特发性肺间质纤维化 被引量:7

Clinical Study of Feiwei Granules Combined with Large Doses of N-acetyl Cysteine in Treatment of Plmonary Fibrosis
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摘要 目的:探讨肺痿冲剂方配合大剂量N-乙酰半胱氨酸二联治疗特发性肺间质纤维化临床效果。方法:选取宁夏第五人民医院石炭井医院2010年2月-2012年2月收治特发性肺间质纤维化患者130例,采用随机数字表法分为对照组和观察组,每组各65例;其中对照组患者采用常规激素疗法;观察组患者采用肺痿冲剂方配合大剂量N-乙酰半胱氨酸二联疗法;比较两组患者临床治疗总有效率,胸部高分辨CT(HRCT)改变阳性率,治疗前后中医证候积分及肺功能指标等。结果:观察组患者临床治疗总有效率明显高于对照组,组间比较差异显著(P<0.05);观察组患者HRCT检查网格影及斑片影改变阳性率均明显低于对照组,组间比较差异显著(P<0.05);经治疗后两组患者中医证候积分较治疗前均显著改善,且观察组患者中医证候积分改善程度较对照组更为明显,组间比较差异显著(P<0.05);观察组患者肺总量(TLC),用力肺活量(FVC)等肺功能指标均较对照组显著改善,组间比较差异显著(P<0.05)。结论:肺痿冲剂方配合大剂量N-乙酰半胱氨酸二联治疗特发性肺间质纤维化与激素治疗相比可有效缓解临床症状、体征,改善肺功能,具有临床应用价值。 Objective: To investigate the therapeutic effect of Feiwei granules combined with large doses of N-acetyl cysteine on plmonary fibrosis. Method: One hundred and thirty patients with plmonary fibrosis were chose during the period from February 2010 to February 2012 in our hospital and randomly divided into two groups including control group (65 patients) with conventional hormone therapy and observation group (65 patients) with Feiwei granules combined with large doses of N-acetyl cysteine ; and the clinical total effective rate, positive rate of change for chest high-resolution CT (HRCT) , before and after treatment symptom scores of traditional Chinese medicine (TCM) and lung function index of both groups were compared. Result: The clinical total effective rate of observation group was significantly higher than control group (P 〈 0.05). The positive rate of change for chest high-resolution CT (HRCT) including grid shadow and patches shadow of observation group were significantly lower than control group (P 〈0. 05). The symptom scores of TCM after treatment in both groups were significantly better than before treatment, and the symptom scores of TCM after treatment of observation group were significantly better than control group (P 〈 0. 05 ). The lung function index including total lung capacity (TLC) and forced vital capacity (FVC) of observation group were significantly better than control group (P 〈 0. 05 ). Conclusion: Compared with conventional hormone therapy, Feiwei Granules combined with large doses of N-acetyl cysteine can efficiently improve clinical symptoms and lung function, and is worthy of clinical application value.
出处 《中国实验方剂学杂志》 CAS 北大核心 2013年第19期314-316,共3页 Chinese Journal of Experimental Traditional Medical Formulae
基金 宁夏市医药科技专项(2010NX328)
关键词 肺痿冲剂方 N-乙酰半胱氨酸 特发性肺间质纤维化 Feiwei granules N-acetyl cysteine plmonary fibrosis
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  • 1徐凌,蔡柏蔷.N-乙酰半胱氨酸在肺部疾病中的应用进展[J].国外医学(呼吸系统分册),2004,24(6):413-416. 被引量:22
  • 2白露,吴晓梅.大剂量富露施对特发性肺间质纤维化患者肺功能的影响[J].中国康复理论与实践,2006,12(7):618-619. 被引量:11
  • 3张晓梅,姜良铎,张伟,吴建军,鲁香凤.肺纤方抗大鼠肺纤维化的实验研究[J].中华中医药杂志,2007,22(6):407-409. 被引量:10
  • 4金·张子和.儒门事亲[M].上海:上海卫生出版社,1958:21,22,23.
  • 5Lynch III J P, White E, Flaherty K. Corticosteroids in idio2 pathic pulmonary fibrosis. Curt Opin Pulmon Med ,2001,7:298.
  • 6Lynch ⅢJ P. Usual interstitial pneumonia. Sen Resp Crit Care Med ,2001 ,22(4) :357.
  • 7Katzenstein AL, Myers JL. Idiopathic pulmonary fibrosis. To biopsy or not to biopsy. Am J Respir Crit Care Med,2001 ,164:185.
  • 8Gillissen A, Nowak D. Characterization of N-acetylcysteine and ambroxol in anti-oxidant therapy [ J ]. Respir Med, 1998 ;92 (4) :609-23.
  • 9American Thoracic Society, European Respiratory Society. American Thoracic Society/European Respiratory Society international multidisciplinary consensus classification of the idiopathic interstitial pneumonias [ J]. Am J Respir Crit Care Med,2002 ;165(2) :277-304.
  • 10Dem P, Sey OJ. Clinical review:idiopathic pulmonary fibrosis-past, present and future [ J 1. Respir Med, 2006 ; 100 ( 11 ) : 1871-85.

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