盐酸舍曲林对亚综合征性抑郁认知功能的治疗作用

The Therapeutic Effect of Sertraline Hydrochloride on Cognitive Dysfunction of Patients with Subsyndromal Symptomatic Depression

目的探讨盐酸舍曲林改善亚综合征性抑郁患者认知功能的临床疗效。方法将我科住院86例亚综合征性抑郁患者依据治疗方案不同,分为:研究组,予以盐酸舍曲林口服,42例;对照组,予以麦普替林口服,44例,两组疗程均为8周。分别于治疗前和治疗后的第1、2、4及8周末采用汉密尔顿抑郁量表(HAMD-17)评定两组临床疗效,采用认知功能筛查量表(CASI)评定两组认知缺损程度,并采用副反应量表(TESS)评定两组的不良反应。结果治疗前两组的HAMD、CASI各分值无差异(t=2.016,P>0.05)。治疗后第2周开始,研究组的HAMD分值低于对照组,而CASI分值则较高(P<0.05)。两组在治疗后第1周末TESS评分差异均无统计学意义,而第2周末开始研究组TESS评分明显小于对照组(t=0.033,P<0.05),且研究组的恶心、食欲下降及心悸发生率较对照组明显降低(P<0.05)。结论盐酸舍曲林能改善亚综合征性抑郁患者认知功能,疗效较好,不良反应少。

Objective To analyze the clinical effect of sertraline hydrochloride on cognitive dysfunction of patients with sub-syn- dromal symptomatic depression（SSD）. Methods A total of 86 patients with SSD in our hospital were divided into two groups,re- search group （42 cases,given by sertraline hydrochloride. ） and control group （44 cases,given by maprotiline. ）. The courses of treat- ment of two groups were both 8 weeks. The clinical effects of two groups were measured by HAMD-17 at the 1st, 2nd,4th,8th weekend,and the cognitive dysfunction were measured by CASI,and the adverse reactions were measured by TESS. Results The scores of HAMD and CASI both two groups were no different（P〈0.05）. Compared to control group,the score of HAMD in re- search group was lower from the 2nd weekend（P〈0.05） ,but the score of CASI in research group was higher from the 2nd week- end （P〈0.05）. The score of TESS in two groups was no different at the 1st weekend （P〈0.05）. But compared to control group, the score of TESS in research group was lower from the 2nd weekend（P〈0. 05）. Compared to control group,the recurrences of nausea,anorexia,palpitation in research group was lower（P〈0.05）. Conclusion The clinical effect of sertraline hydrochloride on SSD is perfect,and the adverse reactions are low.