摘要
目的对比分析帕利哌酮缓释片与奥氮平治疗精神分裂症的临床疗效。方法选取我院2011年6月-2012年6月期间所收治的精神分裂症患者80例,其中应用帕利哌酮缓释片治疗的40例精神分裂症患者设立为观察组,应用奥氮平治疗的40例精神分裂症患者设立为对照组,比较两组的疗效及两组患者治疗前后PANSS评分变化情况、两组不良反应。结果与对照组的总有效率90.0%比较,观察组患者的总有效率虽然略高于对照组,但差异无统计学意义(χ2=2.237,P>0.05),两组患者治疗后的不同时点分别较治疗前比较,差异有显著性(P<0.05);观察组患者治疗后PANSS评分在各个时点均较对照组比较,差异无统计学意义,与对照组的不良反应相比,观察组患者在嗜睡、便秘、流涎、心动过速、体质量增加方面的发生率明显低于对照组(χ2=8.126,P<0.05)。结论帕利哌酮缓释片治疗精神分裂症与奥氮平疗效相当,能明显改善精神症状,且安全性较高,但本研究的样本量较少,帕利哌酮缓释片对于精神分裂症患者的疗效和安全性尚需进一步扩大样本量及长期随访。
Objective To compare the clinical efficacy of palley risperidone sustained-release tablets and olanzapine in the treat- ment of schizophrenia. Methods In our hospital from June 2011 to June 2012,80 cases patients with schizophrenia,including appli- cation palley risperidone sustained release tablets in the treatment of 40 patients with schizophrenia to set up for the observation group,in which the application of the Austrian olanzapine in the treatment of 40 patients with schizophrenia was set up for the con- trol group,the efficacy of two groups of patients before and after treatment PANSS score changes,two sets of adverse reactions were compared between two groups. Results Compared with the control group, the total effective rate of observation group was 90.0% ,the total efficiency rate of observation group was slightly higher than that of the control group,but the difference was not statistically significant (χ2= 2. 237,P〈0.05),respectively over the two groups of patients at different time points after treatment before treatment,the difference was significant (P〈0.05) ;PANSS score after the observation group patients than in the control group at each time point,the difference was not statistically significant (P〈0. 05) ,compared with the control group of adverse ,the observation group were significantly lower than the control group (χz = 8. 126,P〈 0. 05), the incidence of drowsifiess,constipation, salivation,taehyeardia,body mass increases. Conclusion Palley risperidone sustained-release tablets in the treatment of schizophre- nia is similar to olanzapine ,which can significantly improve the psychiatric symptoms,and security,But Because of the small sample size is this study,the efficacy and safety of palley risperidone sustained-release tablets for the spirit schizophrenia patients needs to be further expanded sample size and long-term follow--up.
出处
《中国健康心理学杂志》
2013年第10期1473-1475,共3页
China Journal of Health Psychology
关键词
精神分裂症
帕利哌酮缓释片
奥氮平
不良反应
Schizophrenia
Palley risperidone sustained-release tablets
Olanzapine
Adverse reactions