黄芪保护血管内皮细胞作用机制研究进展

Progress of Studies on Protective Mechanism of Radix Astragali in Vascular Endothelial Cells

目的综述黄芪保护血管内皮细胞作用机制研究进展。方法查阅近年来国内外相关文献,对益气中药黄芪及其有效成分保护血管内皮细胞作用机制研究进行归纳总结。结果黄芪及其有效成分可通过促进内皮细胞增殖,抑制细胞凋亡,促进血管生成,促进一氧化氮合成,干预细胞黏附,改善血管舒张功能,调节内皮活性物质分泌,抗氧化应激等作用,发挥保护血管内皮细胞功能,对于心血管疾病等涉及内皮功能障碍的多种疾病显示重要治疗价值。结论黄芪及其多种成分对血管内皮细胞具有多靶点的保护作用,总结黄芪保护血管内皮细胞作用的机制和特点对于探讨黄芪"益气"功效在血瘀证防治中的应用具有重要的理论价值。

OBJECTIVE To review the progress of studies on protective mechanism of Radix Astragali in vascular endothelial cells. METHODS The summarization of the progress of studies on protective mechanism of tonifying qi chinese medicine Radix As- tragali as well as its effective components in vascular endothelial cells were based on referring to the related literature in recent years. RESULTS The protective function of Radix Astragali as well as its effective components in vascular endothelial cells in means of pro- moting endothelial cells proliferation, inhibiting cells apoptosis, promoting angiogenesis, boosting nitric oxide composition, intervening cells adhesion, ameliorating vasodilatation function, regulating endothelial active substance secretion, antioxidation and so on, revealed significance therapeutic value in cardiovascular diseases and other diseases with endothclum disfunction. CONCLUSION Because of the multiple-targeted protective effect of Radix Astragali in vascular endothelial cells, the summarization of the protective mechanism and character of Radix Astragali in vascular endothelial cells had possessed of vital theoretical value with regard to exploring ＂tonifying qi＂ effective of Radix Astragali in prevention and treatment of blood stasis.