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DC-SIGN在病毒感染中的作用机制研究进展

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摘要 树突状细胞(DCs)表面特异性细胞间黏附分子3结合非整合素(SIGN)主要分布在DCs表面,通过依赖Ca2+的碳水化合物识别区域(CRD)识别与结合内源性和外源性抗原,介导细胞与细胞之间的相互作用,参与DCs对病原体的识别和捕获,在HIV、HCV、登革热病毒(DENV)以及肠道病毒71型(enterovirus 71,EV71)等的感染和传播中发挥重要作用。本文就DC-SIGN与病毒感染相关研究进展作一综述。
作者 张莉 史伟峰
出处 《临床检验杂志》 CAS CSCD 北大核心 2013年第8期599-602,共4页 Chinese Journal of Clinical Laboratory Science
基金 江苏省卫生厅"科教兴卫"医学重点人才项目(Ky0904)
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