老年性黄斑变性的多焦视网膜电图改变

The multifocal electroretinography in age-related macular degeneration

目的 测试并比较正常人和老年性黄斑变性患者的多焦视网膜电图。 方法 应用美国 EDI公司生产的 VERIS science4.0视诱发反应图象系统对 17例 2 0只正常眼、7例 10只老年性黄斑变性 (agerelated maculardegeneration,AMD)干性型眼 ,8例 8只 AMD湿性型眼和 11例 11只特发性黄斑裂孔 (idio-pathic macular hole,IMH)眼进行检测。将各组老年性黄斑变性者 6个环形视网膜区域的 N1 、P1 波潜伏期和平均反应密度值与正常对照组进行比较。 结果 AMD湿性型各环 N1 、P1 波潜伏期和 AMD干性型 3～ 6环处 N1 波潜伏期明显长于正常人。AMD湿性型在 1～ 4环处 N1 波和 1～ 6环处 P1 波平均反应密度值下降 ,AMD干性型在 1～ 5环处 N1 波和 1～ 6环处 P1 波平均反应密度值下降 ,IMH者在 1～ 2环处 N1 、1～ 3环处 P1 波平均反应密度值低于正常人。 结论 多焦视网膜电图可对老年视网膜穿孔黄斑变性部位进行视功能的定量检测。

Purpose To measure and compare the difference of multifocal electroretinogram in normal subjects and patients with age related macular degeneration. Methods Seventeen cases(20 eyes)of normal subjects,7 cases(10 eyes)of dry form AMD(age related macular degeneration),8 cases(8 eyes)of wet form AMD and 11 cases(11 eyes)of idiopathic macular hole(IMH)were tested with VERIS Sciences TM 4.0 made by EDI company of America.The latencies and average response densities of 6 ring retinal regions in normal subjects were compared with those in various types of age related maculopathies. Results The N 1 and P 1 wave latencies of all 6 rings in wet form AMD and the N 1 wave latencies of 3～6 rings in dry form AMD were delayed statistically.The N 1 and P 1 wave average response densities of 1～4 rings in and the P 1 wave average response densities of 1～6 rings wet form AMD and the N 1 wave average response densities of 1～5 and the P 1 wave average response densties of 1～6 rings in dry form AMD were decreased statistically.The N 1 and P 1 wave average response densities of 1～2 and the P 1wave average response densities of 1～3 rings were decrease statistically in IMH. Conclusion Multifocal electroretinogram can be used to quantitate the visual function of the affected location in age related macular degeneration.