2-氨基-4-羟基烟腈的合成

Synthesis of 2-amino-4-hydroxynicotinonitrile

介绍了标题化合物的合成方法。以丙二腈和原乙酸三甲酯为原料,经取代、环合、水解4步反应合成目标化合物。并经MS和1HNMR对其结构进行了表征。本合成路线原料易得,操作简便,后处理方便,反应收率54.37%。

The 2-amino-4-hydroxynicotinonitrile, an important intermediate of adenosine receptor ligands,was synthesized by substitution,cyclization and hydrolysis. The structure was con- firmed by MS and 1HNMR. The total product yield was 54, 37%,