含咪唑的手型二苯基乙二醇衍生物的合成及其在不对称催化中的应用

Synthesis and application in asymmetric reaction of (1R,2R)-hydrobenzoin derivative containing imidazole

以光学纯的(1R,2R)-1,2-二苯基乙二醇和1-甲基-2-氯甲基咪唑盐酸盐为原料,通过醚化保护、取代、脱保护等一系列反应,合成了一种新颖的含氮、氧的手性配体(1R,2R)-2-((1-甲基咪唑基)甲氧基)-1,2-二苯基乙醇,并将其应用于二乙基锌对苯甲醛不对称加成反应中,所得产物e.e.值38%。

Synthesis of novel ehiral ligand （ 1R, 2R ）-2- （ （ 1 -methyl-1 H-imidazol-2-yl） methoxy） -1,2-diphenylethanol containing O,N atoms has been efficiently completed starting from the enantiopure hydrobenzoin and 2-chloromethyl- 1-methylimidazole hydrochloride by etherification, hydroxyl protection, substitution and hydroxyl deprotection. The chiral ligand was used in the enantioselective addition of diethylzinc to benzaldehyde. The yield is about 38%.