基于SRS数据的疏血通注射液不良反应信号预警分析

Spontaneous reportintg system data based on Shuxuetong injection adverse reactions signal warning analysis

该研究以2009年1月—2012年12月国家药品不良反应监测中心疏血通的SRS数据为研究对象,采用报告率比例法与贝叶斯置信传播神经网络法预警疏血通ADR信号,并利用倾向性评分方法平衡混杂因素。结果表明寒战为可能的预警信号。提示临床上使用疏血通注射液时,对于老年人、儿童、肝肾功能低下患者等较易发生不良反应的特殊人群,需注意预防发生全身性的过敏反应,特别是预防寒战的发生。

In this study, January 2009--December 2012 national adverse drug reaction monitoring center Shuxuetong the SRS data for the study, using the reporting rate ratio method and Bayesian belief propagation neural network Shuxuetong ADR warning sig- nal, and balanced use of propensity score methods confounders. The results showed that chilis as a possible warning signal. Tip clinical use Shuxuetong injection when, for the elderly, children, liver and kidney dysfunction are more prone to adverse reactions in patients with other special populations, the need to pay attention to the prevention of systemic allergic reactions, in particular the prevention shivering.