摘要
以天然橙皮素（1）为原料, 与水合肼反应得到了橙皮素腙（2）. 2分别与各种取代的芳香醛反应首次合成了8个N-亚苄基橙皮素腙3～10及6个类似物11～16. 所合成产物通过NMR, IR, HR-ESI-MS方法进行了结构确证. MTT（噻唑蓝）蛋白染色法体外抑制肿瘤增值活性测试发现化合物5, 7, 10, 16对胃癌细胞SGC-7901有显著的抑制活性.
Hesperitin hydrazone （2） was generated by the reaction of natural hesperitin （1） as raw material with hydrazine hydrate. Eight N-benzylidene hesperitin hydrazones 3～10 and six analogues 11～16 were synthesized by the reaction of 2 with various aldehydes, respectively. The structures of all reaction products were confirmed by NMR, IR and HR-MS techniques. And the cytotoxity against human cancer cell SGC-7901 of the synthesized compounds was also evaluated. The results showed 5, 7, 10 and 16 exhibiting distinct cytotoxity against SGC-7901.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2013年第9期1988-1993,共6页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.81060261)
广西科学自然科学基金重点(No.2011jjD20002)资助项目~~
关键词
橙皮素
橙皮素腙
N-亚苄基
细胞活性
hesperitin
hesperitin hydrazones
N-benzylidene
cytotoxicity
