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人类小肠型脂肪酸结合蛋白基因多态性与脂代谢关系的研究进展 被引量：2

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摘要 人类小肠型脂肪酸结合蛋白(FABP2)特异性表达于成熟的小肠上皮细胞。作为脂类伴侣蛋白,在食物中长链脂肪酸的吸收、运输和代谢中发挥着重要的生物学作用。FABP2基因启动子区存在多态性位点,并且由于这些多态性位点的完全连锁不平衡而形成活性不同的两种单倍型A和B(haplotype A,B),具有不同单倍型的FABP2基因表达存在差异。第2外显子54位点存在单核苷酸多态性,即Ala54Thr,此错义突变位点改变了FABP2的结构和功能。近年研究发现,FABP2基因多态性改变与血脂障碍以及代谢综合征的其他特征相关。本文拟从FABP2基因的结构和功能及其多态性与脂代谢关系作一综述。
作者 徐云鹏 常晓彤
机构地区 河北北方学院
出处 《卫生研究》 CAS CSCD 北大核心 2013年第5期863-867,共5页 Journal of Hygiene Research
基金 河北省自然科学基金(No.C2011405015)
关键词 肠型脂肪酸结合蛋白 基因多态性 脂代谢
分类号 Q78 [生物学—分子生物学] Q591 [生物学—生物化学]
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参考文献29

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共引文献16

同被引文献24

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引证文献2

二级引证文献6

卫生研究
2013年 第5期

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