摘要
丙烯酸是一种重要的平台化合物,从它出发可以合成一系列市场广阔、附加值高的产品。传统的丙烯酸化学合成法以不可再生的化石资源为原料,并对环境造成严重污染。本文从可持续发展及环境保护的角度出发,综述丙烯酸的微生物合成途径以及合成关键酶等方面的研究进展,分析探讨不同生物合成途径的优劣之处,并展望利用微生物高产丙烯酸存在的瓶颈以及有潜力的发展方向。
Acrylic acid, an important platform chemical with considerable value and huge mar- ket demand,is widely used in synthesizing a series of commodity chemical. Acrylic acid is conventionally produced from the petrochemical industry. Unfortunately,petrochemical car- bon sources are not renewable and cause serious environmental pollution. In this review, re- search developments on different biosynthetic pathways and enzymes for acrylic acid, were discussed. In addition, the advantages and disadvantages of each pathway were compared and explained. Finally, the existing bottlenecks in biosynthesis of high-yield acrylic acid, and the potential development direction in this field were elucidated.
出处
《广西科学院学报》
2013年第3期149-153,共5页
Journal of Guangxi Academy of Sciences
基金
广西千亿元重大科技攻关工程项目(桂科攻11107008-4)
广西自然科学基金项目(2012GXNSFBA053063
2013GXNSFDA019007)
广西科学研究与技术开发计划项目(桂科重12118004-3
桂科重12118004-4
桂科重1348004-5)
广西科学院基本科研业务费项目(12YJ25SW01
12YJ25SW02)资助
关键词
丙烯酸
平台化合物
微生物催化
可再生资源
代谢工程
acrylic acid, platform chemical, microbial catalysis, renewable carbohydrates, met-abolic engineering
