鸦胆子油亚纳米乳注射液对小鼠移植性肿瘤的抑制作用

Anti-tumor effect of Brucea Javanica oil subnanoemulsion injection against transplanted tumor in mice

目的观察鸦胆子油亚纳米乳注射液对3种小鼠移植性肿瘤的抑制作用。方法应用移植性S180腹水瘤、Heps肝癌细胞、Lewis肺癌细胞荷瘤小鼠,设鸦胆子油亚纳米乳注射液0.45、0.9、1.8 g·kg-13个剂量组,尾静脉给药,计算肿瘤生长抑制率。结果鸦胆子油亚纳米乳注射液低、中、高剂量对小鼠S180腹水瘤的抑制率分别为11.1%、19.5%、33.5%;对小鼠Heps肝癌细胞抑制率分别为12.6%、21.1%、33.0%;对小鼠Lewis肺癌细胞抑制率分别为14.0%、24.9%、42.2%。与模型对照组比较,低剂量组差异无统计学意义(P>0.05),中、高剂量组差异有统计学意义(P<0.05,P<0.01),呈现一定的剂量相关性。结论鸦胆子油亚纳米乳注射液对ICR小鼠S180腹水瘤、Heps肝癌、Lewis肺癌有明显的抑制作用。

Objective To estimate the anti-tumor effect ofBrucea Javanica oil subnanoemulsion injection against 3 models of transplanted tumor in mice. Methods S 180 ascites tumor, Heps hepatoma carcinoma cells, and Lewis lung cancer cells bearing mice were continuously injected by tail venous at 0.45, 0.9 and 1.8 g . kg^ - 1 Results The inhibition rates on S 180 ascites tumor in the mice were 11.1%, 19.5% and 33.5%, respectively; the rates of inhibition on Heps hepatoma carcinoma cells in the mice were 12.6%, 21.1% and 33.0%; the rates of inhibition on Lewis lung cancer cells in mice were 14.0%, 24.9% and 42.2%, respectively. There was no significant difference between the low dose group and the model control group （P 〉 0.05）, but significant difference existed between the middle, high dose group and model control group （P 〈 0.05, P 〈 0.01）, and was dose-dependent. Conclusion Brucea Javanica oil subnanoemulsion injection has an obvious effect on S 180 ascites tumor, Heps hepatoma carcinoma cells, and Lewis lung cancer cells.