期刊文献+

40例运动神经元病临床分析 被引量:3

Clinical Analysis of 40 Cases of Motor Neuron Disease
下载PDF
导出
摘要 收集我院40例运动神经元病患者的临床资料,分析患者运动神经元病亚型的分布及特点。结果显示:肌萎缩侧索硬化患者最多(27例),其次是进行性脊肌萎缩患者(9例)。首发症状多以肢体无力起病,肌电图可发现部分肌肉亚临床性损害。6例患者神经系统MRI有特征性改变。因此认为运动神经元病诊断主要依靠临床特点,肌电图和磁共振检查对运动神经元病诊断有重要意义。
出处 《中国医科大学学报》 CAS CSCD 北大核心 2013年第9期845-846,共2页 Journal of China Medical University
基金 辽宁省自然科学基金(201202276)
  • 相关文献

参考文献10

  • 1Brooks BR,Miller RG,Swash M,et al. E1 escorial revisited criteria for the diagnosis of amyotrophic lateral sclerosis [J]. Amyotroph Lat- eral Seler Other Motor Neuron Disord, 2000,1 ( 5 ) : 293-299.
  • 2Goh KJ,Tian S,Shahrizaila N,et al. Survival and prognostic factors of motor neuron disease in a multi-ethnic Asian population [J]. Mnyotroph Lateral Seler, 2011,12(2) : 124-129.
  • 3MeCombe PA, Henderson RD. Effects of gender in amyotrophie later- al sclerosis [ J ]. Gend Med, 20 lO, 7 (6) : 557- 570.
  • 4Ravits J, Paul P, Jorg C. Foeality of upper and lower motor neuron de- generation at the clinical onset of ALS [ J].Neurology, 2007,68 ( 19 ) : 1571-1575.
  • 5沈定国.直面肌萎缩侧索硬化的早期诊断:从临床研究出发[J].中华神经科杂志,2012,45(7):449-452. 被引量:4
  • 6Kim WK,Ju X,Sander J,et al. Study of 962 patients indicates pro- gressive muscular atrophy is a form of ALS [ J ]. Neurology, 2009,74 (23):686-1692.
  • 7曹丽华,商秀丽,王述森,季春燕,何志义,罗阳.肯尼迪病基因突变分析[J].中国医科大学学报,2011,40(7):577-579. 被引量:4
  • 8徐迎胜,张楠,唐璐,樊东升.上运动神经元损害为主的肌萎缩侧索硬化患者的临床和神经电生理特点[J].中华神经科杂志,2012,45(7):459-462. 被引量:7
  • 9Menke RA, Abraham I,Thiel CS. Fractional anisotropy in the poste- rior limb of the internal capsule and prognosis in amyotrophic later- al sclerosis [J]. Arch Neuro,2012,69( 11 ): 1493-1499.
  • 10Fulimura-Klyono C, Kimura F,et al. Onset and spreading patterns of lower motor neuron involvements predict survival in sporadic amy- otrophic lateral sclerosis [ J ]. J Neural Neurosurg Psychiatry, 2011, 82(11):1244-1249.

二级参考文献67

  • 1鲁明,樊东升,李小英,梁国威,李英,张华纲,康德瑄,张俊,张捷,王晶.基因确诊的肯尼迪病两例临床与分子生物学特点[J].中华神经科杂志,2007,40(4):232-236. 被引量:34
  • 2Kennedy WR,Aher M,Sung JH. Progressive proximal spinal and bulbar muscular atrophy of late onset. A sex-linked recessive trait [J]. Neurology, 1968,18(7) :671-680.
  • 3La Spada AR, Wilson EM, Lubahn DB, et al. Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy [J]. Na- ture, 1991,352(6330) :77-79.
  • 4Finsterer J. Bulbar and spinal muscular atrophy (Kennedy' s dis-ease) : a review [ J ]. Eur J Neurol, 2009,16( 5 ) : 556-561.
  • 5Matsuura T, Ogata A, Demura T, et al. Identification of androgen re- ceptor in the rat spinal motoneurons. Immnnohistochemical and im- munoblotting analyses with monoclonal antibody [J]. Neurosci Lett, 1993,158( 1 ) : 5-8.
  • 6Ogata A, Matsuura T, Tashiro K, et al. Expression of androgen recep- tor in X-linked spinal and bulbar muscular atrophy and amyotrophie lateral sclerosis [ J ]. J Neurol Neurosurg Psychiatry, 1994,57 ( 10 ): 1274-1275.
  • 7Zhou ZX, Lane MV, Kemppainen JA, et al. Specificity of ligand-de- pendent androgen receptor stabilization:receptor domain interactions influence ligand dissociation and receptor stability [J]. Mol En- doerinol, 1995,9(2) :208-218.
  • 8Li M, Miwa S, Kobayashi Y, et al. Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy [J]. Ann Neurol, 1998,44(2) : 249-254.
  • 9Buchanan G, Yang M, Cheong A, et al. Structural and functional con- sequences of glutamine tract variation in the androgen receptor [J]. Hum Mol Genet, 2004,13( 16): 1677-1692.
  • 10Beitel LK,Scan|on T,Gottlieb B,et al. Progress in Spinobu|bar muscular atrophy research:insights into neuronal dysfunction caused by the polyglutamine-expanded androgen receptor [J]. Neurotox Res, 2005,7 ( 3 ) : 219-230.

共引文献12

同被引文献11

引证文献3

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部