黑地黄丸改善慢性肾衰竭患者中医证候的疗效评价

Therapeutic Evaluation of Heidihuang Wan Improvement TCM Syndrome in Patients with Chronic Renal Failure

目的:评价黑地黄丸改善慢性肾衰竭患者中医证候的临床疗效。方法:采用前瞻性,随机、阳性药物平行对照方法进行临床试验,将符合标准的患者随机分为治疗组和对照组,在常规治疗的基础上,治疗组口服黑地黄丸,对照组口服肾康宁片。两组均连续用药2个月后评价疗效。结果:中医证候疗效有效率治疗组为74.07%,对照组为71.43%,组间比较无统计学意义(P>0.05);治疗后两组均能降低患者中医证候积分,与本组治疗前比较有极显著统计学差异(P<0.01),而两组治疗后比较,无统计学差异(P>0.05);治疗组有效率为80.56%,优于对照组63.39%,两组比较有统计学差异(P<0.01)。结论:黑地黄丸能改善慢性肾衰竭患者中医证候,为中医药治疗慢性肾衰竭提出了新的思路与方法。

Objective ： To evaluate the clinical curative effect of Heidihuang Wan improvement TCM syndrome in patients with chronic re- nal failure. Methods：Using prospective, randomized, parallel positive drug control method for clinical trials, patients who conformed to the standards were randomly divided into the treatment group and the control group. On the basis of conventional treatment, the treatment group was given oral Heidihuang Wan, and the control group was given oral Shenkangning Tablet. After 2 months of continuous use drugs in the two groups, the curative effects were evaluated. Effective rate of syndrome curative effect of traditional Chinese medicine in the treatment group was 74.07% ,and the control group was 71.43% ,comparison between the two groups showed that the difference had no statistical significance（ P 〉 0.05） ;After treatment,the patients＇ TCM syndrome integral in the two groups both were declined, and comparison of the rate before and after treatment in the two groups showed both had significant difference（ P 〈 0.01 ） ,while com- parison among two groups after treatment showed the difference had no statistical significance （P 〉 0.05 ）. Results：Effective rate of the treatment group was 80.56%, and the control group was 63.39%, comparison of the two groups showed that the difference was statisti- cally significant （ P 〈 0.01 ）. Conclusion ： Heidihuang Wan can improve the curative effect of TCM syndrome, symptoms of patients with chronic renal failure ,which provide new idea and method for traditional Chinese medicine treatment of chronic renal failure.