中西医结合治疗痛风临床研究

Clinical Research on Gout Patients Treated by Integration of Traditional Chinese and Western Medicine

目的:探讨中西医结治疗痛风病的临床疗效。方法:将104例患者按随机数字表法分为治疗组54例和对照组50例。对照组在急性痛风发作时予以对症治疗(包括秋水仙碱0.5 mg,每日3次,口服,连用3 d[4];布洛芬缓释胶囊0.3 g,每日3次,口服;别嘌醇在急性疼痛缓解后给予,0.1 g,每日1次,口服)。治疗组在对症治疗的基础上加用中药外敷(赤芍、延胡索、乳香、没药、薏苡仁、黄柏、苍术、虎杖)及中药口服(熟附子、细辛、肉桂、干姜、麻黄、三棱、莪术、昆布、海藻、乌梢蛇、黄芪、葛根、当归、茯苓、白芍、白术、续断、鹿含草;兼有湿热征象者,加用黄连、败酱草、黄柏、知母等)治疗。15 d后观察临床疗效。结果:治疗组痊愈率为74.1%,对照组痊愈率为56.0%,两组比较差异有统计学意义(P<0.05);治疗组有效率为96.3%,对照组有效率为92.0%,两组比较无统计学意义(P>0.05);两组治疗后血尿酸与治疗前比较有统计学意义(P<0.05),但治疗组血尿酸水平下降更明显。结论:中西医结合治疗痛风病较单用西医方法治疗效果更好,且降低血尿酸水平更快。

Objective ：To observe the clinical efficacy of integration of traditional Chinese and western medicine treatment of gout pa- tients. Methods ： 104 patients were randomly divided into the treatment group of 54 cases and the control group of 50 cases. The control group was given symptomatic treatment when acute gout attacked （including Colchicine O. 5 mg, three times a day, oral, continous appli- cation of 3 daysE41 ;Ibuprofen Sustained Release Capsule 0.3 g,3 times daily, oral administration;Allopurinol was given after acute pain relief,O. 1 g, 1 time a day, oral administration）. The treatment group on the basis of symptomatic treatment was additionally given exter- nal application with traditional Chinese medicine（ red peony root, rhizoma corydalis, frankincense, myrrh, semen coicis, cortex phelloden- dri, rhizoma atractylodis, polygonum cuspidatum） and oral administration （ composition ： processed aconite root, asarum, cinnamon, dried ginger, ephedra, rhizoma sparganic, rhizoma sparganic, kelp, alga, garter snake, astragalus membranaceus, puerarin, Chinese angelica, po- ria cocos, radix paeoniae alba, rhizoma atractylodis macrocephalae, radix dipsaci, herb pyrolae; Combined with damp-heat symptom, ad- dition use coptis chinensis,patrinia, cortex phellodendri, anemarrhenae, etc. ）. The clinical efficacy was observed after 15 days of treat- ment. Results：The cure rate of treatment group was 74.1% ,and the control group was 56.0% and there was statistically significant in the two groups（ P 〈 0.05 ） ;The effective rate of treatment group was 96.3%, and the control group was 92.0%, and comparison of the two groups showed that the difference was not statistically significant（P 〉 0. 05）. There were statistically significant on blood uric acid （BUA） before and after the treatments in the two group （P 〈 0. 05 ）. But the level of dropping BUA in the treatment group was more ob- vious than the control group. Conclusion：The efficiency of integration of traditional and western medicine treating gout disease is better than the pure western medicine, and lowering blood uric acid level faster.