ICAM-3蛋白在宫颈鳞癌组织中的表达及临床意义

Expression and clinical significance of intercellular adhesion molecule- 3 in cervical squamous cell carcinoma tissue

目的：研究宫颈鳞癌组织中细胞间粘附分子（intercellular cell adhesion molecule，ICAM）-3的表达及意义。方法：采用免疫组织化学S—P法检测45例宫颈鳞癌组织、30例宫颈上皮内瘤变（Cervical Intraepithelial Neoplasm，CIN）组织及15例宫颈正常组织中ICAM-3蛋白的表达，分析ICAM-3在不同宫颈组织中的表达情况以及ICAM-3与宫颈鳞癌患者临床分期、肿瘤直径、组织学分级及淋巴结转移的关系。结果：宫颈鳞癌组织中ICAM-3阳性表达率为71．1％（32／45），显著高于其在正常宫颈组织中的阳性表达率6．0％（1／15）及在CINⅡ-Ⅲ组中的阳性表达率40．0％（12／30）；ICAM-3在有淋巴结转移组阳性表达率为87．0％（20／23），高于无淋巴结转移组54．5％（12／22）；在不同分化程度的癌组织中其阳性率也有一定差异，Ⅰ级与Ⅱ、Ⅲ级之间差异有统计学意义（P〈0．05）。结论：ICAM-3蛋白高表达与宫颈鳞癌的发生、发展密切相关。

Objective： To research the expression and clinical significance of intercellular adhesion molecule -3 （ICAM -3 ） in cervical squamous cell carcinoma tissue. Methods ： Immunohistochemical SP method was used to detect the expression levels of ICAM - 3 in specimens of 45 cases with cervical squamous cell carcinoma, 30 cases with cervical intraepithelial neoplasm （CIN） , and 15 cases with normal cervical squamous cell epithelium. The expression levels of ICAM - 3 in different cervical tissues and its relationship with clinical stages, tumor diameter, histological grades, and lymph node metastasis were analyzed. Results： The positive expression rate of ICAM -3 in cervical squamous cell carcinoma was 71.1% （32/45）, which was significantly higher than those in normal cervical tissue （6. 0%, 1/15 ） and CIN Ⅱ - m （40 0%, 12/30）; the positive expression rate of ICAM -3 in lymph node metastasis group was 87. 0% （20/23）, which was significantly higher than that in non -lymph node metastasis group （54. 5%, 12/22） ; there was statistically significant difference in positive expression rate of ICAM - 3 among cervical squamous cell carcinoma of grade Ⅰ and grade Ⅱ, Ⅲ （P 〈 0. 05） . Conclusion ： The up - regulation of ICAM - 3 protein is closely correlated with occurrence and development of cervical squamous cell carcinoma.