阿司匹林对大鼠心梗后诱导心肌纤维化的预防作用

Preventive effect of aspirin on myocardial fibrosis induced by myocardial infarction in rats

目的:观察阿司匹林对心梗后诱导的心肌纤维化的预防作用。方法:对大鼠采用左冠动脉结扎建立心梗模型,以随机原则将实验大鼠分为阿司匹林组、模型组和假手术组,建模4周、8周后分别检测3组血流动力学相关参数,之后分离大鼠心脏并观察心肌纤维化相关参数。结果:在血流动力学方面,4周时模型组左心室收缩压(LVSP),左室舒张末期压(LVEDP),左心室最大收缩速率(+d max/dt)及左心室最大舒张速率(-d min/dt)均明显低于假手术组,差异有统计学意义(P均<0.01)。阿司匹林组LVEDP相比模型组明显升高(P<0.05)。8周时模型组LVSP、LVEDP、LVMP、+d max/dt以及-d max/dt均显著低于假手术组(P均<0.05)。阿司匹林组LVSP、LVEDP、LVMP、+d max/dt和-d max/dt相比模型组明显升高(P均<0.05)。心肌纤维化方面:与假手术组相比,4周和8周时模型组LVAW,HL,HL/L维生素D和LVAW/LVD均降低,LVD增大(P均<0.05)。使用了阿司匹林后这些指标均有明显的改善。结论:阿司匹林对心梗后诱导的心肌纤维化有一定的改善作用,这一结论可以为临床预防心梗后诱导的心肌纤维化提供依据。

OBJECTIVE To observe the preventive effect of aspirin on myocardial fibrosis induced by myocardial infarction. METHODS Myocardial infarction model was established by ligaturing left coronary artery in rats. The rats were divided into 3 groups randomly： the aspirin group, the model group and the sham-operated group. Cardiac hemodynamic parameters in 3 groups were obtained 4 weeks later and 8 weeks later. Myocardial fibrosis parameters were measured after the rats＇ hearts were taken out and dissected. RESULTS The parameters of cardiac hemodynamics： 4 weeks later, the level of LVSP （left ventricular systolic pressure）, LVEDP （left ventricular end diastolic pressure）, ＋ dnx/dt （maximum rate of left ventricular contraction） and dmx/dt （maximum rate of left ventrieular diastolic） of the model group were lower than that of the sham-operated group （all P%0. 01）. The level of LVEDP of the aspirin group was higher than that of the model group （P %0. 05）. 8 weeks later, the level of LVSP, LVEDP, LVMP, ＋ dmx/dt and -dmax/dt of the model group was lower than that of the sham opera- ted group （all P %0. 05）. The level of LVSP, LVEDP, LVMP, ＋ dx/dt and -dr,x/dt of the aspirin group was higher than that of the model group （all P%0. 05）. The parameters of myocardial fibrosis： The level of LVAW, HL, HI./ LVD and LVAW/LVD of the model group was lower than that of the sham-operated group when the level of LVD was higher（all P〈0. 05）. The parameters were improved when aspirin was used. CONCLUSION Aspirin has certain improving effects on myo-cardial fibrosis induced by myocardial infarction, the conclusion can provide the basis for prevention of myocardial fibrosis in duced by myocardial infarction in clinic.