摘要
背景丙泊酚麻醉导致的患者术后认知功能障碍（postoperative cognitive dysfunction，POCD）日益引起关注，但其相关机制尚不清楚。目的针对丙泊酚导致POCD碍机制的研究进展进行综述，为临床上对该术后并发症的预防和治疗提供参考。内容结合国内外相关的非颅脑手术的实验及临床研究，对丙泊酚可能引起POCD的各种机制进行阐述。趋向丙泊酚是经典的静脉麻醉药之一，只有了解其对认知功能的影响，才能有效地避免或者减少POCD的发生，并且这些研究也会成为以后指导临床用药的指南。
Background The postoperative cognitive dysfunction （POCD） induced by propofol has drawn more and more attention recently, but its machanism is still unclear. Objective By reviewing the researches on the mechanisms of postoperative cognitive dysfunction caused by propofol, we may provide some references for the prevention and treatment of POCD clinically. Content Summerize the investigational advances of POCD caused by propofol anesthesia. Trend Propofol is one of the classic intravenous anesthetics. The study of its influence to cognitive function would decrease the morbidity of POCD, and also guide the further clinical practice.
出处
《国际麻醉学与复苏杂志》
CAS
2013年第10期917-920,共4页
International Journal of Anesthesiology and Resuscitation
关键词
丙泊酚
非颅脑手术
认知功能
Propofol
Non-craniocerebral operation
Cognitive function
