凝结芽孢杆菌活菌片联合益生菌低聚糖粉治疗妊娠期便秘的临床观察

Effects of Bacillus Coagulans tablets and oligosaccharides powder on pregnant women with constipation

目的观察和评价凝结芽孢杆菌活菌片(商品名:爽舒宝)联合益生菌低聚糖粉治疗妊娠期便秘的临床疗效。方法将100例妊娠期便秘患者随机分为治疗组和对照组,治疗组60例,对照组40例,两组均给予基础治疗。其中治疗组在此基础上同时口服凝结芽孢杆菌活菌片和益生菌低聚糖粉,凝结芽孢杆菌活菌片首次2.1 g,以后1.05 g/次,3次/d;益生菌低聚糖粉10 g/次,3次/d,温水送服,疗程14 d。观察治疗前后便秘改善情况。结果治疗组总有效率、大便频率明显高于对照组,差异有统计学意义(P<0.05)。结论凝结芽孢杆菌活菌片联合益生菌低聚糖粉治疗妊娠期便秘疗效显著,值得临床推广。

Objective To observe and evaluate the effects of Bacillus Coagulans tablets and oligosaccharides powder for treatment of constipation in pregnant women. Methods One hundred pregnant women with constipation were randomly divided into treatment group （n = 60） and control group （n = 40）. Both groups were given basic treatment. In treatment group, Bacillus Coagulans tablets were ad- ministered at doses of 2.1 g the first time and then 1.05 g each time, three times a day; Probiotics oligosaccharides powder was adminis- tered at doses of 10 g each time, three times a day. The period of treatment was 14 days. The improvement of constipation symptoms was observed before and after treatment. Results Compared to the control group, the total effective rate and defecate frequency in treatment group were significantly higher, and the differences were statistically significant （P 〈 0.05 ）. Conclusion Bacillus Coagulans tablets combined with oligosaccharides powder is remarkably effective for the treatment of constipation in pregnancy.