摘要
L-肌肽(β-丙氨酸-L-组氨酸)在哺乳动物骨骼肌中合成。L-肌肽可影响自主神经系统相关的生理功能,通过影响所支配器官和组织的交感及副交感神经活性引起血压、血糖、食欲、脂质分解和产热等生理功能的变化。然而,由L-肌肽引发的生理功能的变化又能因组胺H1、H3受体拮抗剂或生物钟主钟视交叉上核(SCN)双侧损伤而解除。因此,主要概述在生物钟和组胺能神经的参与下,L-肌肽通过自主神经途径调节血糖、血压、脂质分解和产热等生理机能的相关研究进展。
L-carnosine （β-alanyl-L-histidine） is synthesized in mammalian skeletal muscle. It is reported that L-carnosine affects physiological functions through the autonomic nerves system. In particular, L-carnosine affects the activity of sympathetic and parasympathetic nerves to further induce changes in blood pressure, blood glucose, appetite, lipolysis and thermogenesis. The changes in physiological functions mediated by L-carnosine are eliminated by histamine H1 or H3 receptor antagonists and bilateral lesions of the hypothalamic suprachiasmatic nucleus （SCN）, a master circadian clock. This article briefly reviews the advances on the effects of L-carnosine on physiological functions such as blood glucose, blood pressure, lipolysis, and thermogenesis via autonomic nerves system and with the involvement of the circadian clock and histaminergic neurons.
出处
《生命科学》
CSCD
2013年第9期891-896,共6页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金青年科学基金项目(31200890)
浙江省自然科学基金项目(Y3090563)
浙江省新苗人才计划项目(2012R403008)
关键词
L-肌肽
交感神经
副交感神经
生物钟
组胺能神经
L-carnosine
sympathetic nerve
parasympathetic nerve
circadian clock
histaminergic neurons
