62例早期乳腺癌保乳术后疗效及局部复发因素分析

The effect and the analysis of local-regional recurrence factors for 62 patients with early-stage breast cancer after breast-conserving surgery

回顾性分析62例早期乳腺癌保乳治疗患者临床资料，采用Log—Rank检验及Cox比例风险模型分析年龄、激素受体情况、肿瘤大小、淋巴结情况、病理类型、放疗方法等因素对局部一区域复发的影响。随访22～96个月，中位48个月。全组1、3、5年生存率分别为100％、93．3％、89．6％。局部一区域复发率为6．5％，术后局部一区域复发的高峰时间为术后2—3年。单因素分析显示年龄、人表皮生长因子-2（HER-2）表达状态是影响局部一区域复发的危险因素，多因素分析显示年龄是复发的独立影响因素。

The date base of 62 patients with early-stage breast cancer was analyzed respectively. Age, ER/PR, HER-2, tumor diameter,lymph node and pathological status were studied by Log-Rank testing and Cox model to analyse the factors of local-regional recurrence. The median follow-up was 48 （ 22 - 96） months. The 1,3,5-year overall survival rates were 100%, 93.3%, and 89.6% respectively. Localegional recurrence rate was 6.5%. The peak recurrence period was the 2nd and 3nd year from operation. Age and HER-2 status were significant risk factors for local-regional recurence in univariate analysis. The age was independent factors of local-regional recurrence in multivariate analysis.