弥散张量成像对高血压前期患者隐匿性脑损伤的临床研究

A clinical analysis of increasing blood pressure on subtle brain injury in asymptomatic young adults

目的运用弥散张量成像(DTI)定量研究不同血压水平的变化对无症状正常人脑白质部位的各向异性特点。方法选择临床无症状正常人60例,按血压水平分为3组,均行DTI检查。分析其表面弥散系数(ADC)图及各向异性分数(FA)图的特点,并对各组相同部位的脑白质进行ADC值及FA值行定量分析,通过统计学分析得出其弥散系数和各向异性特点。结果 DTI可清晰显示脑内白质的走形及方向。不同血压水平对相同年龄组相同解剖部位脑白质ADC值及FA值的差异有统计学意义。FA值能准确定量分析无症状正常人脑白质部位的各向异性特点。结论血压的升高,可造成脑血管的缓慢损伤。即使在无症状正常人中,微小的血管性脑损伤也可在生活中隐匿性发生,并产生明显的影像学效应。研究强调了早期控制血压达标的重要性。

Objective To evaluate the effects of increasing blood pressure on white-matter integrity in asymptomatic young adults with diffusion tensor imaging technology. Methods Sixty asymptomatic young adults were divided to normal group,prehypertension group and hypertension group according to their blood pressure levels. The ADC values and FA val- ues were measured. We analysed diffusiom tensor imaging measures of fractional anisotropy and mean diffusivity. And the statistical analysis data was established. Results DTI could display the cerebral white matter fibers ~ell. There were sta- tistical differences among FA values and ADC values of different groups. FA values could be used to analyze the anisotropy of cerebral white matter fibers in different adults groups quantitatively. Conclusion Increased blood pressure is associated with clinically concomitant subtle brain injuries, even for asymptomatic young adults. Our results emphasise the need for early and optimuM control of blood pressure.