左旋多巴甲酯在PLGA微球的稳定性研究

Stability of Levodopa Methyl Ester-loaded PLGA Microspheres

目的:考察左旋多巴甲酯在PLGA微球中的稳定性并探讨其稳定方法。方法:利用HPLC的方法考察了左旋多巴甲酯在不同pH值和光照的环境中和微球里的稳定性。结果:左旋多巴甲酯在pH 3中稳定,在微球中也可以稳定一周。结论:包封左旋多巴甲酯在PLGA微球中,是一种有效地保护了左旋多巴甲酯在微球中的活性,可以实现长效缓释,是一种可行的方案。

Objective： To develop an effective method and analysis of stability levodopa methyl ester. Methods： Stability of levodopa methyl ester in different pH, illumination and in PLGA microspheres were analyzed by HPLC method. Results： Levodopa methyl ester can be stabilized at pH 3 and in PLGA microspheres for 1 week. Conclusion： The preparation of PLGA microspheres of levodopa methyl ester through the encapsulation method can protect the bioactivity of the levodopa methyl ester in the microspheres. This method is an effective technique for levodopa methyl ester sustained release.