可溶性血小板内皮细胞黏附分子1及P选择素在孤独症患儿中的表达及其意义

Expression of soluble platelet endothelial cell adhesion molecule-1 and P-selectin and the significance in children with autism

目的 探讨可溶性血小板内皮细胞黏附分子1（PECAM-1）及P选择素（P-selectin）在孤独症患儿中的表达情况及其临床意义.方法 采用ELISA法对12例孤独症儿童及15例健康儿童血清中PECAM-1及P-selectin水平进行检测,并通过孤独症患儿评定量表（ABC量表）对孤独症患儿进行评分.对PECAM-1水平及ABC量表评分进行相关性分析.结果 孤独症患儿的PECAM-1水平高于健康对照组儿童,而P-selectin水平则低于健康对照组儿童,差异均有统计学意义（t=2.06、2.05,P均＜0.05）；PECAM-1水平与孤独症患儿ABC量表得分呈正相关（r=0.67,P=0.017）.结论 PECAM-1作为免疫系统代表性免疫因子可能参与孤独症患儿中枢神经系统的免疫过程,且与孤独症患儿的ABC量表评分相关,提示孤独症与免疫因素有关.

Objective To investigate the expressions of soluble platelet endothelial cell adhesion molecule-1 （PECAM-1） and P-selectin and the clinical significance in autistic children.Methods Enzyme-linked immunosorbent assay （ELISA） was used to detect serum PECAM-1 and P-selectin levels in 12 autistic children and 15 healthy children,the autistic children were scored by using Antecedent Behavior Consequence （ABC） Chart,and correlation analysis of PECAM-1 and ABC Chart was performed.Results The PECAM-1 level in autistic children was higher than that in healthy control group（t =2.06,P ＜ 0.05）,and the P-selectin level was lower than that in healthy control group （t =2.05,P ＜ 0.05）,at the same time,PECAM-1 level was positively correlated with the ABC scores in autistic children （r =0.67,P =0.017）.Conclusions PECAM-1 as a representation of the immune system immune factors may be involved in the central nervous immune process of autistic children,which is related to ABC chart scores of autistic children.Also it prompts that autism is related to immune factors.