中风病痰湿证与垂体-肾上腺激素水平关系的探讨

Studies on the Relationship between the Phlegm-Wet Zheng Type ofIschemic Cerebral Vascular Accident and Pituitary-Adrenal CorticalAxial Hormones Levels

目的 :探讨中风病痰湿证与垂体 -肾上腺激素水平关系 ,以从微观角度寻找中风症证候的辨证依据。方法 :应用“证候辨证量化”诊断的方法对151例经CT或MRI确诊为缺血性中风始发态的患者进行量化评分 ,将其分为痰湿证和非痰湿证两组 ,同时用放射免疫分析(RIA)法测定本病患者及健康体检者的促肾上腺皮质激素(ACTH)、皮质醇(CS)含量并进行对照。结果 :两组患者ACTH、CS含量均升高 ,与健康对照组比较具有非常显著的差异(P<0.001)。而痰湿证组ACTH、CS含量较非痰湿证组高 ,两组比较有统计学意义(P<0.05)。结论 :缺血性中风痰湿证与ACTH、CS有密切关系 。

Objective To find a differential diagnostic rule for ischemic cerebral vascular accident through studies on the relationship between phlegm-wet zheng types and pituitary-adrenalcortical axial bormones levels. Methods 151 ischemic cerebral vasaular accident patients (diagnosed with CT or MRI) were scored with “Quantified Sympton-complex differentiation” method and were divided in to phlegm-wet-positive and negative types. Plasms ACTH and CS levels were determined with RIA in both groups as well as in 60 controls. Results Plasma levels of ACTH and CS were significanty higher in both groups of patients than those in the controls (P<0.001); while levels in the phlegm-wet positive type patients were significantly higher those in the phlegm-wet negative type (P<0.05). Conclusion The phlegm-wet symptom complex in acute carebral ischemia was closely related to an imcrease of ACTH and CS secretion, which might serve as a type-differential diagnosis reference guide.