摘要
目的:探讨改良电痉挛治疗(MECT)对首发抑郁症治疗的疗效及安全性。方法:将180例首发抑郁症患者随机分为两组,分别为单用氯咪帕明(下称对照组)组和氯咪帕明与电痉挛治疗联合应用组(下称联用组),观察时间为8周。于基线及治疗1、2、4、6、8周末,采用汉密尔顿抑郁量表(HAMD)评定疗效,采用不良反应症状量表(TESS)和心电图评价治疗的安全性。最终纳入分析联用组和对照组各88例。结果:联用组自治疗第1周末、对照组自治疗第4周末,HAMD焦虑/躯体化、认识障碍、阻滞、绝望感四个因子分和总分显著下降,与基线的差异具有统计学意义(P<0.05);自治疗第6周末始两组患者的HAMD全部7个因子分相比无统计学差异。8周观察中未发现二者对心电图有明显影响。结论:改良电痉挛治疗对首发抑郁症的治疗有良好的疗效,而且起效迅速,安全性较好,对记忆功能早期有一定影响,一般在1个月左右恢复。
Objective： To discuss therapeutic efficacy and safety of MECT in first- episode depressive pa- tients. Methods：We divided 180 depressive patients into combined treated group and contrasted group randomly , then observing 8 weeks. To evaluate therapeutic efficacy with HANID at baseline and lth , 2th , 4th , 6th, 8th weekend. To evaluate therapeutic safety with TESS and electrocardiogram changes. Ultimately we analyze 88 patients in each group respectively. Result：There are four kinds of factor （HAMD anxiety/somatization, aware- ness barriers, block, hopelessness）score and total score have significant decrease since the first weekend in two groups and since the 4th weekend in contrasted group . There are significant difference contrast with baseline（P 〈 0.05 or P 〈 0.01 ）. There are no significant difference in 7 kinds of factor score of HAMD since 6th weekend in two groups. There are no significant effect to ECG in 8 weeks. Conclusion： In ourinvestigation , MECT shows favorable therapeutic efficacy and rapid exert effect and nicer safety as well as.
出处
《内蒙古医学杂志》
2013年第6期650-653,共4页
Inner Mongolia Medical Journal
基金
内蒙古卫生厅医疗卫生科研计划项目(2009040)
关键词
改良电痉挛治疗
氯咪帕明
抑郁症
Modified F!ectric Convulsive Therapy
Clomipramine depressionion
