致病性奇异变形杆菌和大肠杆菌混合感染致奶牛关节脓肿和腹泻的研究

Study on Mix Infection of Pathogenic Proteus mirabillis and E. coli Causing Joint Abscess and Diarrhea of Dairy Cows

试验旨在查明2012年底甘肃省某奶牛场奶牛关节脓肿和腹泻的病因并选择合适的治疗药物。经牛病毒性腹泻黏膜病毒(BVDV)和牛轮状病毒(BRV)检测、细菌分离鉴定、小鼠致病性试验、药敏试验及血清中钙磷含量测定等综合分析,确诊该病是由致病性奇异变形杆菌和大肠杆菌混合感染引起的。这2种分离菌对青霉素、阿莫西林、庆大霉素、卡那霉素、四环素、氟哌酸及复方新诺明等常用药物严重耐药,均对氟苯尼考中度敏感。经氟苯尼考治疗和加强饲养管理后该病得到有效控制。

In order to identify the cause of joint abscess and diarrhea of dairy cows in Gansu province and choose sensitive drugs for treatment,clinical samples were isolated and identified by BVDV and BRV detection, bacteria isolation and culture, mouse pathogenicity, antibiotic sensitivity tests and content detection of Ca and P in the sera which were collected from diary cows suffering from joint abscess and diarrhea. The results showed that mix infection of pathogenic Proteus mirabilis and E. coli causing joint abscess and diarrhea of dairy cows. The two isolates were medium sensitive to florfenicol, resistant to penicil- lin,amoxicillin, gentamicin, kanamycin neomycin,tetracycline, norfloxacin and cotrimoxazole. This disease was controlled by the treatment of florfenicol and enhancing feeding management.