附睾特异谷胱甘肽过氧化物酶基因调控的研究进展

Research Progress on the Regulation of Epididymal Specific Glutathione Peroxidase (GPx5) Gene

附睾特异谷胱甘肽过氧化物酶(epididymal specific glutathione peroxidase,GPx5)可保护精子免受氧化应激,维持精子遗传信息的完整性,促进精子发育成熟,其重要生理功能在提高动物繁殖力上有着不可替代的作用,但其基因调控转录表达的机制尚不明确。现作者主要对基因表达特性、表达调控和转录调控等内容进行综述。

Epididymal specific glutathione peroxidase （GPx5） protected sperms from oxidative stress, maintained the integ- rity of sperm genetic information and promoted sperms to develop, its physiological functions played an irreplaceable role in im- proving animal reproduction. But the mechanism of its gene expression regulation of transcription was not yet clear. Based on the achievements the concerning literature had been made, the study had carried on the summary of characteristics, expression and regulation of gene expression and transcription regulation, etc.