L-核糖的生产研究进展

Research progress in production of L-ribose

L-核糖是合成许多抗病毒药物的关键中间体,自然界和生物体中并不存在。L-核糖的制备方法有化学合成法和生物合成法。与化学合成法相比,生物合成法对环境更加有利。生物合成法是应用微生物及其酶以核糖醇或L-阿拉伯糖为原料生产L-核糖。综述了L-核糖的制备方法以及产品的分离纯化技术,并对L-核糖的研究现状和前景进行了展望。

L-ribose is a non-natural and expensive sugar that can be used as an important intermediate for the synthesis of L-nucleoside analogues. Compared with chemical production, biotechnological methods can produce L-ribose from biomass under environmentally friendly conditions. Various strategies for synthesizing L-ribose by applying microorganisms and their enzymes are discussed, including producing L-ribose from ribitol and L-arabinose. Furthermore, subsequent isolation-and-purification techniques, as an integral step in the whole process, are described, containing the especial introduction of a promising strategy of L-ribose separation. Particularly, further researches and outlook for the improvement of L-ribose preparation are solely stressed. Compared with each method, the mini-review will launch a discussion on the production of L-ribose and its prospect.