食管静脉曲张粘膜硬化加固治疗间隔时间研究

On Treatment Interval of Mucosal Reinforcement for Esophageal Varices

目的探讨粘膜硬化加固术更加合理的治疗间隔时间。方法选择食管静脉曲张破裂出血经套扎后曲张静脉消失或基本消失的患者169例,随机分为隔1月粘膜加固组(87例)和隔2周粘膜加固组(82例),分别采取间隔1月和间隔2周的粘膜硬化加固治疗。观察食管静脉曲张复发率、再出血率、并发症发生率、总住院时间和住院费用。结果隔1月粘膜加固组并发症发生率、总住院时间和住院费用明显低于隔2周粘膜加固组,而两组食管静脉曲张复发率、再出血率无统计学差异。结论 1个月的粘膜硬化加固治疗间隔时间较2周更加优化合理。

Objective To explore the optimal treatment interval of mucosal reinforcement.Methods A total of 169 patients were randomly divided into group of one-month interval（87 cases） and group of two-week interval（82 cases）,who had bleeding due to esophageal varices that disappeared or almost disappeared after receiving ligation.The former group received mucosal reinforcement treatment every other month and the latter every two weeks.The recurrence rate of varices,bleeding,and incidence of complication,total hospital stay and costs were observed in both groups.Results The incidence of complication,total hospital stay and costs were obviously less in group of one-month interval than in group of two-week interval.However,no significant difference was found in the recurrence rate of varices and bleeding in both groups.Conclusion One-month interval is better than two-week interval for mucosal reinforcement.