摘要
目的:调查某院使用解热药造成的儿童不良反应(ADR)情况,总结其发生的原因和规律,探讨处置对策,促进药物的合理应用。方法:回顾性分析2008年1月-2013年1月该院患儿应用解热药时发生的278例ADR报告,从性别与年龄、涉及的药品种类、给药途径、累及器官或系统及临床表现、治疗及转归等方面进行分类和统计。结果:278例ADR报告涉及药品21种,其中双黄连注射液居首位(占12.59%);ADR造成的损害累及9个器官或系统类型,以皮疹、瘙痒等皮肤及其附件损害为主。结论:临床应用解热药于儿童时,应严格掌握适应证、控制给药剂量、加强监护,以减少ADR的发生。
OBJECTIVE: To investigate the occurrence of pediatric adverse drug reaction (ADR) induced by antipyretic in a hospital, and to summarize the regularity and to study disposal measures in order to promote rational drug use. METHODS: By ret- rospective study, 278 ADR reports collected from the hospital during Jan. 2008--Jan. 2013 were analyzed statistically in terms of gender and age, drug types, route of administration, organs or systems involved in ADR, clinical manifestations, treatment and prognosis, etc. RESULTS: Among 278 cases of ADR, a total of 21 kinds of drugs were involved, among which Shuanghuanglian injection took the lead (12.59%) ; the injuries of ADR involved 9 organs/systems; main clinical manifestations of ADR was lesion of skin and its appendants as erythra and pruritus. CONCLUSIONS: When applying antipyretic in children, the doctor should strictly use drugs according to the indications, control the medication dose and strengthen the care to reduce the occurrence of ADR.
出处
《中国药房》
CAS
CSCD
2013年第38期3621-3623,共3页
China Pharmacy
关键词
解热药
儿童
不良反应
Antipyretic
Children
Adverse drug reaction