四川自贡地区育龄期妇女口服维A酸类药的误用妊娠风险调查

Survey about the Pregnancy Risk by Misuse of Oral Retinoic Acid Agents in Women of Childbearing Age from Zigong Area in Sichuan

目的:了解口服维A酸类药在四川自贡地区育龄期妇女人群中误用的妊娠风险。方法:选取50家代表性零售药店(自贡市区30家、富顺县10家、荣县10家)进行药店调查;选取16家医院(自贡市区10家、富顺县3家、荣县3家)进行医院调查。结果:12家药店(自贡市区8家、富顺县4家)有口服维A酸类药销售,其售药过程中无一家药店的药师向患者提示妊娠风险;有4家医院(自贡市区3家、富顺县1家)销售有口服维A酸类药物,这4家医院的8名皮肤科医师中,仅有1位皮肤科医师未向患者提示妊娠风险。结论:自贡地区口服维A酸类药物药店误用风险较大,医院误用风险较小。卫生行政部门应当积极采取措施,减少育龄期妇女可能误服维A酸类药导致的妊娠风险。

OBJECTIVE： To understand the pregnancy risk by misuse of oral retinoic acid agents in women of childbearing age ~om Zigong area in Sichuan. METHODS： 50 representative retail drugstores （30 drugstores in Zigong city, 10 in Fushun county, 10 hospitals in Rung county） were selected for drugstores investigation and 16 hospitals （10 hospitals in Zigong county, 3 in Fush- un county, 3 in Rong county） were chosen to conduct hospital investigation. RESULTS： 12 drugstores had sales of oral retinoic ac- id drugs （8 drugstores in Zigong city, 4 in Fushun county）, but none of the pharmacist warned patient about pregnancy risk. 4 hos- pitals （3 hospitals in Zigong city, 1 in Fushun＇ county） had sales of oral retinoic acid drug, in which 8 dermatologists were sur- veyed and only 1 physician did not warn patient about pregnancy risk. CONCLUSIONS： There are high misuse risks of oral retino- ic acid drugs in drugstores from Zigong area but low misuse risk in the hospitals. Health administrative department should adopted active measures to reduce pregnancy risk induced by misuse of retinoic acid drugs in women of childbearing age