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原癌基因Bmi-1与头颈部恶性肿瘤 被引量：1

Proto-oncogene Bmi-1 and head and neck cancer
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摘要 Bmi-1基因是多梳基因家族的核心成员之一。作为一种原癌基因，Bmi-1基因在细胞的自我更新、增殖及凋亡方面发挥重要作用。多项研究已证实，Bmi-1基因在鼻咽癌、喉癌等多种头颈部恶性肿瘤中均有异常表达，并与肿瘤的发生、发展、侵袭、预后密切相关。Bmi-1基因有望成为一种新的肿瘤分子标志物，为头颈部恶性肿瘤的诊断、治疗提供新的方向和手段。 Bmi-1 is a core member of the polycomb group genes. As a proto-oncogene, Bmi-1 plays an important role in cell self-renewal, proliferation and apoptosis. Several studies have shown that Bmi-1 is highly expressed in some head and neck malignant tumors, such as nasopharyngeal cancer and laryngeal carcinoma. Furthermore, the expression level of Bmi-I is closely related to the occurrence, development, incursion and prognosis of tumor. Bmi-1 is expected to become a novel tumor molecular marker, and provides a new direction for the treatment of the head and neck malignant tumor.
作者 高珊 王仁生
机构地区 广西医科大学第一附属医院放疗科
出处 《国际肿瘤学杂志》 CAS 2013年第9期665-668,共4页 Journal of International Oncology
关键词 基因 头颈部肿瘤 BMI-1 Genes Head and neck neoplasms Bmi-1
分类号 R739.91 [医药卫生—肿瘤]
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参考文献23

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二级参考文献21

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共引文献3

同被引文献22

  • 1Yadirgi G, Leinster V, Acquati S, et al. Conditional activation of Bmi-l expression regulates self-renewal, apoptosis, and differentiation of neural stem/progenitor cells in vitro and in vivo[J].Stem Cells.2011, 29(4):700-712.
  • 2Cohen KJ, Hanna JS, Prescott JE, et al. Transformation by the Bmi-1 oncoprotein correlates with its subnuclear localization but not its transcriptional suppression activity[J]. Mol Cell Biol, 1996, 16(10): 5527-5535.
  • 3Xin T, Zhang FB, Sui GJ, et al. Bmi-1 siRNA inhibited ovarian cancer cell line growth and decreased telomerase activity[J]. Br J Biomed Sci, 2012, 69(2): 62-66.
  • 4Alkema MJ, Wiegant J, Raap AK, et al. Characterization and chromosomal localization of the human proto-oncogene Bmi-1[J].Hum Mol Genet.1993, 2(10):1597-1603.
  • 5Lee K, Adhikary G, Balasubramanian S, et al. Expression of Bmi-1 in epidemis enhances cell survivalby altering cell cycle regulatory protein expression and inhibiting apoptosis[J].J Invest Dennatol.2008, 128(1):9-10.
  • 6Vonlanthen S, Heighway J, Altermatt HJ, et al. The Bmi-1 oncoprotein is differentially expressed in non small cell lung cancer and correlates with INK4A-ARF locus expression[J].Br J Cancer.2001, 84(10):1372-1376.
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  • 9Silva J, García JM, Pea C, et al. Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, hTERT, and c-myc expression in primary breast carcinomas[J].Clin Cancer Res.2006, 12(23):6929-6936.
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国际肿瘤学杂志
2013年 第9期

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